Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis
Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial effects in humans and animals. Many of the biological functions of PUFAs are mediated via bioactive metabolites produced by fatty acid oxyg...
Gespeichert in:
| Veröffentlicht in: | International immunology 2019-09, Vol.31 (9), p.559-567 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 567 |
|---|---|
| container_issue | 9 |
| container_start_page | 559 |
| container_title | International immunology |
| container_volume | 31 |
| creator | Ishihara, Tomoaki Yoshida, Mio Arita, Makoto |
| description | Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial effects in humans and animals. Many of the biological functions of PUFAs are mediated via bioactive metabolites produced by fatty acid oxygenases such as cyclooxygenases, lipoxygenases and cytochrome P450 monooxygenases. Liquid chromatography-tandem mass spectrometry-based mediator lipidomics revealed a series of novel bioactive lipid mediators derived from omega-3 PUFAs. Here, we describe recent advances on omega-3 PUFA-derived mediators, mainly focusing on their enzymatic oxygenation pathway, and their biological functions in controlling inflammation and tissue homeostasis. |
| doi_str_mv | 10.1093/intimm/dxz001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2183182719</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2183182719</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-fa56c18ad0ddaf16fdb8bdd3b1e28bd67c5ed651b475197ae9666a4d3df7193c3</originalsourceid><addsrcrecordid>eNpNkDtPwzAYRS0EoiUwsiKPLKF23NjJiCpeUqUudI6--EGN4rjYDqL8elqlIKZ7h6MzHISuKbmjpGYz2yfr3Ex9fRNCT9CUzjnJCybE6b8_QRcxvhNCWFGzczRhRIiipuUUrVdOv0HOsIGUdhikVbnSwX5qhZ1WFpIPEacNJCx9n4LvsO1NB85Bsr7H0CucbIyDxhvvtI8Joo2X6MxAF_XVcTO0fnx4XTzny9XTy-J-mUtW8pQbKLmkFSiiFBjKjWqrVinWUl3sDxey1IqXtJ2LktYCdM05h7liyghaM8kydDt6t8F_DDqmxtkodddBr_0Qm4JWjFbFAc5QPqIy-BiDNs02WAdh11DSHEo2Y8lmLLnnb47qod2H-KN_07EfzKJzRA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2183182719</pqid></control><display><type>article</type><title>Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Ishihara, Tomoaki ; Yoshida, Mio ; Arita, Makoto</creator><creatorcontrib>Ishihara, Tomoaki ; Yoshida, Mio ; Arita, Makoto</creatorcontrib><description>Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial effects in humans and animals. Many of the biological functions of PUFAs are mediated via bioactive metabolites produced by fatty acid oxygenases such as cyclooxygenases, lipoxygenases and cytochrome P450 monooxygenases. Liquid chromatography-tandem mass spectrometry-based mediator lipidomics revealed a series of novel bioactive lipid mediators derived from omega-3 PUFAs. Here, we describe recent advances on omega-3 PUFA-derived mediators, mainly focusing on their enzymatic oxygenation pathway, and their biological functions in controlling inflammation and tissue homeostasis.</description><identifier>ISSN: 1460-2377</identifier><identifier>EISSN: 1460-2377</identifier><identifier>DOI: 10.1093/intimm/dxz001</identifier><identifier>PMID: 30772915</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - metabolism ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Fatty Acids, Omega-3 - chemistry ; Fatty Acids, Omega-3 - metabolism ; Fatty Acids, Omega-3 - pharmacology ; Homeostasis - drug effects ; Homeostasis - immunology ; Humans ; Inflammation - drug therapy ; Inflammation - immunology ; Inflammation - metabolism ; Molecular Structure</subject><ispartof>International immunology, 2019-09, Vol.31 (9), p.559-567</ispartof><rights>The Japanese Society for Immunology. 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-fa56c18ad0ddaf16fdb8bdd3b1e28bd67c5ed651b475197ae9666a4d3df7193c3</citedby><cites>FETCH-LOGICAL-c356t-fa56c18ad0ddaf16fdb8bdd3b1e28bd67c5ed651b475197ae9666a4d3df7193c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30772915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishihara, Tomoaki</creatorcontrib><creatorcontrib>Yoshida, Mio</creatorcontrib><creatorcontrib>Arita, Makoto</creatorcontrib><title>Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis</title><title>International immunology</title><addtitle>Int Immunol</addtitle><description>Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial effects in humans and animals. Many of the biological functions of PUFAs are mediated via bioactive metabolites produced by fatty acid oxygenases such as cyclooxygenases, lipoxygenases and cytochrome P450 monooxygenases. Liquid chromatography-tandem mass spectrometry-based mediator lipidomics revealed a series of novel bioactive lipid mediators derived from omega-3 PUFAs. Here, we describe recent advances on omega-3 PUFA-derived mediators, mainly focusing on their enzymatic oxygenation pathway, and their biological functions in controlling inflammation and tissue homeostasis.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - metabolism</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Fatty Acids, Omega-3 - chemistry</subject><subject>Fatty Acids, Omega-3 - metabolism</subject><subject>Fatty Acids, Omega-3 - pharmacology</subject><subject>Homeostasis - drug effects</subject><subject>Homeostasis - immunology</subject><subject>Humans</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - immunology</subject><subject>Inflammation - metabolism</subject><subject>Molecular Structure</subject><issn>1460-2377</issn><issn>1460-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAYRS0EoiUwsiKPLKF23NjJiCpeUqUudI6--EGN4rjYDqL8elqlIKZ7h6MzHISuKbmjpGYz2yfr3Ex9fRNCT9CUzjnJCybE6b8_QRcxvhNCWFGzczRhRIiipuUUrVdOv0HOsIGUdhikVbnSwX5qhZ1WFpIPEacNJCx9n4LvsO1NB85Bsr7H0CucbIyDxhvvtI8Joo2X6MxAF_XVcTO0fnx4XTzny9XTy-J-mUtW8pQbKLmkFSiiFBjKjWqrVinWUl3sDxey1IqXtJ2LktYCdM05h7liyghaM8kydDt6t8F_DDqmxtkodddBr_0Qm4JWjFbFAc5QPqIy-BiDNs02WAdh11DSHEo2Y8lmLLnnb47qod2H-KN_07EfzKJzRA</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Ishihara, Tomoaki</creator><creator>Yoshida, Mio</creator><creator>Arita, Makoto</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190901</creationdate><title>Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis</title><author>Ishihara, Tomoaki ; Yoshida, Mio ; Arita, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-fa56c18ad0ddaf16fdb8bdd3b1e28bd67c5ed651b475197ae9666a4d3df7193c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - metabolism</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Fatty Acids, Omega-3 - chemistry</topic><topic>Fatty Acids, Omega-3 - metabolism</topic><topic>Fatty Acids, Omega-3 - pharmacology</topic><topic>Homeostasis - drug effects</topic><topic>Homeostasis - immunology</topic><topic>Humans</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - immunology</topic><topic>Inflammation - metabolism</topic><topic>Molecular Structure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishihara, Tomoaki</creatorcontrib><creatorcontrib>Yoshida, Mio</creatorcontrib><creatorcontrib>Arita, Makoto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishihara, Tomoaki</au><au>Yoshida, Mio</au><au>Arita, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis</atitle><jtitle>International immunology</jtitle><addtitle>Int Immunol</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>31</volume><issue>9</issue><spage>559</spage><epage>567</epage><pages>559-567</pages><issn>1460-2377</issn><eissn>1460-2377</eissn><abstract>Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial effects in humans and animals. Many of the biological functions of PUFAs are mediated via bioactive metabolites produced by fatty acid oxygenases such as cyclooxygenases, lipoxygenases and cytochrome P450 monooxygenases. Liquid chromatography-tandem mass spectrometry-based mediator lipidomics revealed a series of novel bioactive lipid mediators derived from omega-3 PUFAs. Here, we describe recent advances on omega-3 PUFA-derived mediators, mainly focusing on their enzymatic oxygenation pathway, and their biological functions in controlling inflammation and tissue homeostasis.</abstract><cop>England</cop><pmid>30772915</pmid><doi>10.1093/intimm/dxz001</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1460-2377 |
| ispartof | International immunology, 2019-09, Vol.31 (9), p.559-567 |
| issn | 1460-2377 1460-2377 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2183182719 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacology Fatty Acids, Omega-3 - chemistry Fatty Acids, Omega-3 - metabolism Fatty Acids, Omega-3 - pharmacology Homeostasis - drug effects Homeostasis - immunology Humans Inflammation - drug therapy Inflammation - immunology Inflammation - metabolism Molecular Structure |
| title | Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T12%3A59%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Omega-3%20fatty%20acid-derived%20mediators%20that%20control%20inflammation%20and%20tissue%20homeostasis&rft.jtitle=International%20immunology&rft.au=Ishihara,%20Tomoaki&rft.date=2019-09-01&rft.volume=31&rft.issue=9&rft.spage=559&rft.epage=567&rft.pages=559-567&rft.issn=1460-2377&rft.eissn=1460-2377&rft_id=info:doi/10.1093/intimm/dxz001&rft_dat=%3Cproquest_cross%3E2183182719%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2183182719&rft_id=info:pmid/30772915&rfr_iscdi=true |