Evaluation of p16/Ki-67 dual staining in the detection of cervical precancer and cancer in China

•Co-expression of p16 and Ki-67 indicated transformation, supposed to be more specific.•p16/Ki-67 was similar to HR-HPV in sensitivity but specificity was higher.•p16/Ki-67 had a good clinical performance for triage of women with ASC-US.•p16/Ki-67 is promising for use in China’s national cervical ca...

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Veröffentlicht in:	Cancer epidemiology 2019-04, Vol.59, p.123-128
Hauptverfasser:	Zhang, Shao-Kai, Jia, Man-Man, Zhao, Dong-Mei, Wu, Ze-Ni, Guo, Zhen, Liu, Yu-Ling, Guo, Pei-Pei, Chen, Qiong, Cao, Xiao-Qin, Liu, Shu-Zheng, Chen, Wen, Sun, Xi-Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biopsy Cancer Cancer screening Cell cycle Cellular biology Cervical cancer Cervical Intraepithelial Neoplasia - diagnosis Cervical Intraepithelial Neoplasia - etiology Cervix China Clinical performance Colposcopy Consent Cyclin-Dependent Kinase Inhibitor p16 - analysis Cyclin-dependent kinases Cytology Deoxyribonucleic acid DNA DNA testing Early Detection of Cancer Epidemiology FDA approval Female Genetic testing Gynecology Human papillomavirus Humans Ki-67 Antigen - analysis Medical screening Middle Aged P16/Ki-67 dual staining Papillomavirus Infections - complications Population Precancer Pregnancy Sensitivity Sensitivity and Specificity Staining Staining and Labeling Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - etiology Womens health Young Adult
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