Suspected adverse effects after human papillomavirus vaccination: a temporal relationship
In Japan, a significant number of adolescent girls complained unusual symptoms after human papillomavirus (HPV) vaccination, and the vast majority of them were initially diagnosed as having psychiatric illness because of the absence of pathologic findings, radiological images and specific abnormalit...
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| Veröffentlicht in: | Immunologic research 2018-12, Vol.66 (6), p.723-725 |
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| creator | Ikeda, Shu-ichi Hineno, Akiyo Ozawa, Kazuki Kinoshita, Tomomi |
| description | In Japan, a significant number of adolescent girls complained unusual symptoms after human papillomavirus (HPV) vaccination, and the vast majority of them were initially diagnosed as having psychiatric illness because of the absence of pathologic findings, radiological images and specific abnormalities in laboratory test results. Later, these symptoms were supposed to be adverse effects after HPV vaccination, and the recommendation for HPV vaccination was withdrawn by Japanese Ministry of Public Health, Labour and Welfare 4 years and 9 months ago. However, a causal link has not been demonstrated between HPV vaccination and the development of these symptoms. Our study has shown that the period of HPV vaccination considerably overlapped with that of unique postvaccination symptom development, adding that new patients with possible HPV vaccine-related symptoms have not appeared during our recent 28-month follow-up period. This social episode has now subsided in Japan. |
| doi_str_mv | 10.1007/s12026-018-9063-y |
| format | Article |
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Later, these symptoms were supposed to be adverse effects after HPV vaccination, and the recommendation for HPV vaccination was withdrawn by Japanese Ministry of Public Health, Labour and Welfare 4 years and 9 months ago. However, a causal link has not been demonstrated between HPV vaccination and the development of these symptoms. Our study has shown that the period of HPV vaccination considerably overlapped with that of unique postvaccination symptom development, adding that new patients with possible HPV vaccine-related symptoms have not appeared during our recent 28-month follow-up period. 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Later, these symptoms were supposed to be adverse effects after HPV vaccination, and the recommendation for HPV vaccination was withdrawn by Japanese Ministry of Public Health, Labour and Welfare 4 years and 9 months ago. However, a causal link has not been demonstrated between HPV vaccination and the development of these symptoms. Our study has shown that the period of HPV vaccination considerably overlapped with that of unique postvaccination symptom development, adding that new patients with possible HPV vaccine-related symptoms have not appeared during our recent 28-month follow-up period. 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| subjects | Abnormalities Adverse Drug Reaction Reporting Systems Allergology Biomedical and Life Sciences Biomedicine Drug-Related Side Effects and Adverse Reactions - etiology Girls Human papillomavirus Humans Immunization Immunology Internal Medicine Japan Laboratory tests Medicine/Public Health Papillomaviridae - immunology Papillomavirus Vaccines - adverse effects Public health Review Side effects Signs and symptoms Vaccination Vaccination - adverse effects |
| title | Suspected adverse effects after human papillomavirus vaccination: a temporal relationship |
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