APOE Genotype Specific Effects on the Early Neurodegenerative Sequelae Following Chronic Repeated Mild Traumatic Brain Injury

Repeated mild traumatic brain injury (r-mTBI) can potentially manifest into chronic traumatic encephalopathy (CTE). The apolipoprotein E (APOE4) genotype, a well-recognized potent genetic risk factor in age-related neurodegenerative diseases such as Alzheimer's disease, has been linked to worse...

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Veröffentlicht in:	Neuroscience 2019-04, Vol.404, p.297-313
Hauptverfasser:	Muza, Phillip, Bachmeier, Corbin, Mouzon, Benoit, Algamal, Moustafa, Rafi, Naomi G., Lungmus, Carlyn, Abdullah, Laila, Evans, James E., Ferguson, Scott, Mullan, Michael, Crawford, Fiona, Ojo, Joseph O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals APOE4 Apolipoprotein E3 - genetics Apolipoprotein E3 - metabolism Apolipoprotein E4 - genetics Apolipoprotein E4 - metabolism astrocytes Brain Concussion - genetics Brain Concussion - metabolism Brain Concussion - pathology Chronic Disease Female Genotype Male Mice Mice, Transgenic microglia mild TBI Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology phospholipid tau
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