Inhibition of Nrf2 promotes the antitumor effect of Pinelliae rhizome in papillary thyroid cancer

We previously reported that Xiaotan Sanjie (XTSJ) decoction can prevent the progression of gastric cancer in vitro and in vivo. Pinelliae rhizome (PR), one component of XTSJ decoction, has an inhibitory effect on the growth and proliferation of tumor cells. The present study investigated the underly...

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Veröffentlicht in:	Journal of cellular physiology 2019-08, Vol.234 (8), p.13867-13877
Hauptverfasser:	Du, Zhipeng, Wang, Qiang, Ma, Guanjun, Jiao, Jianpeng, Jiang, Daozhen, Zheng, Xiangmin, Qiu, Ming, Liu, Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Animals Anticancer properties Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity Apoptosis Aquatic plants Autophagy Biotechnology Cancer Cell Line, Tumor Cell Nucleus - drug effects Cell Nucleus - metabolism Cell proliferation Cell Survival - drug effects Cell viability Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Gastric cancer Humans MAP kinase MAP Kinase Signaling System - drug effects MAPK pathway Mice, Inbred C57BL Mice, Knockout NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - metabolism Nrf2 Papillary thyroid cancer Phagocytosis Pinellia - chemistry Pinelliae rhizome siRNA Surgical implants Thyroid Thyroid cancer Thyroid Cancer, Papillary - drug therapy Thyroid Cancer, Papillary - pathology Thyroid Neoplasms - drug therapy Thyroid Neoplasms - pathology Tumor cell lines Tumor cells Tumors Xiaotan Sanjie decoction
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