Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

Regulatory T (T reg ) cells, an immunosuppressive subset of CD4 + T cells characterized by the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a component of the immune system with essential roles in maintaining self-tolerance. In addition, T reg cells can suppress...

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Veröffentlicht in:	Nature reviews. Clinical oncology 2019-06, Vol.16 (6), p.356-371
Hauptverfasser:	Togashi, Yosuke, Shitara, Kohei, Nishikawa, Hiroyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/67 692/699/67/1059/2325 692/699/67/327 692/699/67/580 692/700/565/251 Antigen-presenting cells Antigens Apoptosis Autoantigens Biomarkers, Tumor - immunology Cancer Cancer therapies Care and treatment CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Cell death CTLA-4 Antigen - antagonists & inhibitors CTLA-4 protein Cytotoxicity Effector cells Forkhead protein Forkhead Transcription Factors - metabolism Foxp3 protein Genetic aspects Health aspects Homeostasis Humans Immune checkpoint inhibitors Immune response Immune Tolerance Immunological tolerance Immunoregulation Immunosuppression Immunosurveillance Immunotherapy Interleukin 2 Lymphocytes Lymphocytes T Medicine Medicine & Public Health Methods Neoplasms - drug therapy Neoplasms - immunology Oncology Patient outcomes PD-1 protein Peripheral blood Phenotype Phenotypes Precision Medicine Programmed Cell Death 1 Receptor - antagonists & inhibitors Review Article T cells T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Therapeutic applications Tumors
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