Associated vitamin D deficiency is a risk factor for the complication of HCV-related liver cirrhosis including hepatic encephalopathy and spontaneous bacterial peritonitis
The influence of vitamin D, 25-hydroxyvitamin D (25(OH)D), deficiency on hepatitis C virus (HCV)-related cirrhosis had been poorly elucidated especially in patients with hepatic encephalopathy (HE) and spontaneous bacterial peritonitis (SBP). We aimed to investigate the association between vitamin D...
Gespeichert in:
| Veröffentlicht in: | Internal and emergency medicine 2019-08, Vol.14 (5), p.753-761 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 761 |
|---|---|
| container_issue | 5 |
| container_start_page | 753 |
| container_title | Internal and emergency medicine |
| container_volume | 14 |
| creator | Yousif, Monkez Moteih Sadek, Ayman Magd Eldin Mohammad Farrag, Hesham Ahmad Selim, Fayrouz Othman Hamed, Emad Fawzi Salama, Rasha Ibrahim |
| description | The influence of vitamin D, 25-hydroxyvitamin D (25(OH)D), deficiency on hepatitis C virus (HCV)-related cirrhosis had been poorly elucidated especially in patients with hepatic encephalopathy (HE) and spontaneous bacterial peritonitis (SBP). We aimed to investigate the association between vitamin D deficiency and the risk of SBP or HE, including the mortality rate. Serum 25(OH)D levels were prospectively determined in 135 patients. Of them, 45 patients had complications with HE and 45 patients had complications with SBP; 45 cirrhotic patients without complication served as the control group. Vitamin D deficiency was defined as 25(OH)D levels |
| doi_str_mv | 10.1007/s11739-019-02042-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179511903</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2174079719</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-1e7b34889fb8b2e5931ee099c0e12ae84a535a2959cd578fea964a7d0815da883</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhSMEoqXwAiyQJTZsAv6JY3tZ3QJFqsQG2FqOM2lcHDvYTqX7TLwkblNAYsFiNB75O2dGOk3zkuC3BGPxLhMimGoxqUVxR1v6qDklSuBWsb5_XN-SyhZ3nThpnuV8gzHnPRFPmxOGBe4pZ6fNz_Oco3WmwIhuXTGLC-gCjTA56yDYI3IZGZRc_o4mY0tMaKpVZkA2Lqt31hQXA4oTujx8axP4eyfvbiEh61KaY64OLli_jS5coxnWqrCoesM6Gx_rOB-RCSPKawzFBIhbRkPdBckZj9baSgyuuPy8eTIZn-HFQz9rvn54_-Vw2V59_vjpcH7VWiZ4aQmIgXVSqmmQAwWuGAHASlkMhBqQneGMG6q4siMXcgKj-s6IEUvCRyMlO2ve7L5rij82yEUvLlvwfj9OUyIUJ0RhVtHX_6A3cUuhXndHdVgoQVSl6E7ZFHNOMOk1ucWkoyZY30Wp9yh1jVLfR6lpFb16sN6GBcY_kt_ZVYDtQK5f4RrS393_sf0F2rus3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2174079719</pqid></control><display><type>article</type><title>Associated vitamin D deficiency is a risk factor for the complication of HCV-related liver cirrhosis including hepatic encephalopathy and spontaneous bacterial peritonitis</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Yousif, Monkez Moteih ; Sadek, Ayman Magd Eldin Mohammad ; Farrag, Hesham Ahmad ; Selim, Fayrouz Othman ; Hamed, Emad Fawzi ; Salama, Rasha Ibrahim</creator><creatorcontrib>Yousif, Monkez Moteih ; Sadek, Ayman Magd Eldin Mohammad ; Farrag, Hesham Ahmad ; Selim, Fayrouz Othman ; Hamed, Emad Fawzi ; Salama, Rasha Ibrahim</creatorcontrib><description>The influence of vitamin D, 25-hydroxyvitamin D (25(OH)D), deficiency on hepatitis C virus (HCV)-related cirrhosis had been poorly elucidated especially in patients with hepatic encephalopathy (HE) and spontaneous bacterial peritonitis (SBP). We aimed to investigate the association between vitamin D deficiency and the risk of SBP or HE, including the mortality rate. Serum 25(OH)D levels were prospectively determined in 135 patients. Of them, 45 patients had complications with HE and 45 patients had complications with SBP; 45 cirrhotic patients without complication served as the control group. Vitamin D deficiency was defined as 25(OH)D levels < 20 ng/ml. Receiver operating characteristic (ROC) and Kaplan–Meier method with log-rank test were used in our statistical analysis. Predictors of survival were determined using Cox regression analysis. Serum 25(OH)D levels were significantly (
P
< 0.05) lower in the HE and SBP groups than in the control group (6.81 ± 2.75, 7.15 ± 2.10, 16.28 ± 6.60, respectively). Moreover, serum 25(OH)D levels were significantly lower in the high HE grade than in the low grade (
P
< 0.001). Regarding the SBP group, classic SBP was associated with lower 25(OH)D levels compared to other types (
P
< 0.001). ROC curve revealed that lower 25(OH)D levels less than 7.1 ng/ml and 6.6 ng/ml could predict the mortality in SBP and HE patients, respectively, with high sensitivity and specificity. Serum 25(OH)D levels < 5 ng/ml were associated with significant higher mortality rate (HR = 2.76,
P
= 0.001). Lower 25(OH)D levels were associated with HE and SBP in cirrhotic patients. In addition, it may be considered a prognostic parameter for the severity of liver cirrhosis.</description><identifier>ISSN: 1828-0447</identifier><identifier>EISSN: 1970-9366</identifier><identifier>DOI: 10.1007/s11739-019-02042-2</identifier><identifier>PMID: 30706253</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>25-Hydroxyvitamin D ; Aged ; Analysis of Variance ; Bacterial Infections - complications ; Bacterial Infections - physiopathology ; Cirrhosis ; Complications ; Egypt ; Female ; Hepacivirus - pathogenicity ; Hepacivirus - physiology ; Hepatic encephalopathy ; Hepatic Encephalopathy - blood ; Hepatic Encephalopathy - etiology ; Hepatic Encephalopathy - physiopathology ; Hepatitis ; Hepatitis C ; Humans ; Im - Original ; Internal Medicine ; Liver ; Liver cirrhosis ; Liver Cirrhosis - blood ; Liver Cirrhosis - etiology ; Liver Cirrhosis - physiopathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Peritonitis ; Peritonitis - blood ; Peritonitis - etiology ; Peritonitis - physiopathology ; Prospective Studies ; Rank tests ; Regression analysis ; Risk Factors ; ROC Curve ; Statistical analysis ; Viruses ; Vitamin D ; Vitamin D - analysis ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - epidemiology ; Vitamin deficiency</subject><ispartof>Internal and emergency medicine, 2019-08, Vol.14 (5), p.753-761</ispartof><rights>Società Italiana di Medicina Interna (SIMI) 2019</rights><rights>Internal and Emergency Medicine is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-1e7b34889fb8b2e5931ee099c0e12ae84a535a2959cd578fea964a7d0815da883</citedby><cites>FETCH-LOGICAL-c375t-1e7b34889fb8b2e5931ee099c0e12ae84a535a2959cd578fea964a7d0815da883</cites><orcidid>0000-0002-1095-1411</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11739-019-02042-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11739-019-02042-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30706253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yousif, Monkez Moteih</creatorcontrib><creatorcontrib>Sadek, Ayman Magd Eldin Mohammad</creatorcontrib><creatorcontrib>Farrag, Hesham Ahmad</creatorcontrib><creatorcontrib>Selim, Fayrouz Othman</creatorcontrib><creatorcontrib>Hamed, Emad Fawzi</creatorcontrib><creatorcontrib>Salama, Rasha Ibrahim</creatorcontrib><title>Associated vitamin D deficiency is a risk factor for the complication of HCV-related liver cirrhosis including hepatic encephalopathy and spontaneous bacterial peritonitis</title><title>Internal and emergency medicine</title><addtitle>Intern Emerg Med</addtitle><addtitle>Intern Emerg Med</addtitle><description>The influence of vitamin D, 25-hydroxyvitamin D (25(OH)D), deficiency on hepatitis C virus (HCV)-related cirrhosis had been poorly elucidated especially in patients with hepatic encephalopathy (HE) and spontaneous bacterial peritonitis (SBP). We aimed to investigate the association between vitamin D deficiency and the risk of SBP or HE, including the mortality rate. Serum 25(OH)D levels were prospectively determined in 135 patients. Of them, 45 patients had complications with HE and 45 patients had complications with SBP; 45 cirrhotic patients without complication served as the control group. Vitamin D deficiency was defined as 25(OH)D levels < 20 ng/ml. Receiver operating characteristic (ROC) and Kaplan–Meier method with log-rank test were used in our statistical analysis. Predictors of survival were determined using Cox regression analysis. Serum 25(OH)D levels were significantly (
P
< 0.05) lower in the HE and SBP groups than in the control group (6.81 ± 2.75, 7.15 ± 2.10, 16.28 ± 6.60, respectively). Moreover, serum 25(OH)D levels were significantly lower in the high HE grade than in the low grade (
P
< 0.001). Regarding the SBP group, classic SBP was associated with lower 25(OH)D levels compared to other types (
P
< 0.001). ROC curve revealed that lower 25(OH)D levels less than 7.1 ng/ml and 6.6 ng/ml could predict the mortality in SBP and HE patients, respectively, with high sensitivity and specificity. Serum 25(OH)D levels < 5 ng/ml were associated with significant higher mortality rate (HR = 2.76,
P
= 0.001). Lower 25(OH)D levels were associated with HE and SBP in cirrhotic patients. In addition, it may be considered a prognostic parameter for the severity of liver cirrhosis.</description><subject>25-Hydroxyvitamin D</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Bacterial Infections - complications</subject><subject>Bacterial Infections - physiopathology</subject><subject>Cirrhosis</subject><subject>Complications</subject><subject>Egypt</subject><subject>Female</subject><subject>Hepacivirus - pathogenicity</subject><subject>Hepacivirus - physiology</subject><subject>Hepatic encephalopathy</subject><subject>Hepatic Encephalopathy - blood</subject><subject>Hepatic Encephalopathy - etiology</subject><subject>Hepatic Encephalopathy - physiopathology</subject><subject>Hepatitis</subject><subject>Hepatitis C</subject><subject>Humans</subject><subject>Im - Original</subject><subject>Internal Medicine</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - etiology</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Peritonitis</subject><subject>Peritonitis - blood</subject><subject>Peritonitis - etiology</subject><subject>Peritonitis - physiopathology</subject><subject>Prospective Studies</subject><subject>Rank tests</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Statistical analysis</subject><subject>Viruses</subject><subject>Vitamin D</subject><subject>Vitamin D - analysis</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin deficiency</subject><issn>1828-0447</issn><issn>1970-9366</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1u1TAQhSMEoqXwAiyQJTZsAv6JY3tZ3QJFqsQG2FqOM2lcHDvYTqX7TLwkblNAYsFiNB75O2dGOk3zkuC3BGPxLhMimGoxqUVxR1v6qDklSuBWsb5_XN-SyhZ3nThpnuV8gzHnPRFPmxOGBe4pZ6fNz_Oco3WmwIhuXTGLC-gCjTA56yDYI3IZGZRc_o4mY0tMaKpVZkA2Lqt31hQXA4oTujx8axP4eyfvbiEh61KaY64OLli_jS5coxnWqrCoesM6Gx_rOB-RCSPKawzFBIhbRkPdBckZj9baSgyuuPy8eTIZn-HFQz9rvn54_-Vw2V59_vjpcH7VWiZ4aQmIgXVSqmmQAwWuGAHASlkMhBqQneGMG6q4siMXcgKj-s6IEUvCRyMlO2ve7L5rij82yEUvLlvwfj9OUyIUJ0RhVtHX_6A3cUuhXndHdVgoQVSl6E7ZFHNOMOk1ucWkoyZY30Wp9yh1jVLfR6lpFb16sN6GBcY_kt_ZVYDtQK5f4RrS393_sf0F2rus3w</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Yousif, Monkez Moteih</creator><creator>Sadek, Ayman Magd Eldin Mohammad</creator><creator>Farrag, Hesham Ahmad</creator><creator>Selim, Fayrouz Othman</creator><creator>Hamed, Emad Fawzi</creator><creator>Salama, Rasha Ibrahim</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1095-1411</orcidid></search><sort><creationdate>20190801</creationdate><title>Associated vitamin D deficiency is a risk factor for the complication of HCV-related liver cirrhosis including hepatic encephalopathy and spontaneous bacterial peritonitis</title><author>Yousif, Monkez Moteih ; Sadek, Ayman Magd Eldin Mohammad ; Farrag, Hesham Ahmad ; Selim, Fayrouz Othman ; Hamed, Emad Fawzi ; Salama, Rasha Ibrahim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-1e7b34889fb8b2e5931ee099c0e12ae84a535a2959cd578fea964a7d0815da883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Bacterial Infections - complications</topic><topic>Bacterial Infections - physiopathology</topic><topic>Cirrhosis</topic><topic>Complications</topic><topic>Egypt</topic><topic>Female</topic><topic>Hepacivirus - pathogenicity</topic><topic>Hepacivirus - physiology</topic><topic>Hepatic encephalopathy</topic><topic>Hepatic Encephalopathy - blood</topic><topic>Hepatic Encephalopathy - etiology</topic><topic>Hepatic Encephalopathy - physiopathology</topic><topic>Hepatitis</topic><topic>Hepatitis C</topic><topic>Humans</topic><topic>Im - Original</topic><topic>Internal Medicine</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - etiology</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Peritonitis</topic><topic>Peritonitis - blood</topic><topic>Peritonitis - etiology</topic><topic>Peritonitis - physiopathology</topic><topic>Prospective Studies</topic><topic>Rank tests</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Statistical analysis</topic><topic>Viruses</topic><topic>Vitamin D</topic><topic>Vitamin D - analysis</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yousif, Monkez Moteih</creatorcontrib><creatorcontrib>Sadek, Ayman Magd Eldin Mohammad</creatorcontrib><creatorcontrib>Farrag, Hesham Ahmad</creatorcontrib><creatorcontrib>Selim, Fayrouz Othman</creatorcontrib><creatorcontrib>Hamed, Emad Fawzi</creatorcontrib><creatorcontrib>Salama, Rasha Ibrahim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Internal and emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yousif, Monkez Moteih</au><au>Sadek, Ayman Magd Eldin Mohammad</au><au>Farrag, Hesham Ahmad</au><au>Selim, Fayrouz Othman</au><au>Hamed, Emad Fawzi</au><au>Salama, Rasha Ibrahim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associated vitamin D deficiency is a risk factor for the complication of HCV-related liver cirrhosis including hepatic encephalopathy and spontaneous bacterial peritonitis</atitle><jtitle>Internal and emergency medicine</jtitle><stitle>Intern Emerg Med</stitle><addtitle>Intern Emerg Med</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>14</volume><issue>5</issue><spage>753</spage><epage>761</epage><pages>753-761</pages><issn>1828-0447</issn><eissn>1970-9366</eissn><abstract>The influence of vitamin D, 25-hydroxyvitamin D (25(OH)D), deficiency on hepatitis C virus (HCV)-related cirrhosis had been poorly elucidated especially in patients with hepatic encephalopathy (HE) and spontaneous bacterial peritonitis (SBP). We aimed to investigate the association between vitamin D deficiency and the risk of SBP or HE, including the mortality rate. Serum 25(OH)D levels were prospectively determined in 135 patients. Of them, 45 patients had complications with HE and 45 patients had complications with SBP; 45 cirrhotic patients without complication served as the control group. Vitamin D deficiency was defined as 25(OH)D levels < 20 ng/ml. Receiver operating characteristic (ROC) and Kaplan–Meier method with log-rank test were used in our statistical analysis. Predictors of survival were determined using Cox regression analysis. Serum 25(OH)D levels were significantly (
P
< 0.05) lower in the HE and SBP groups than in the control group (6.81 ± 2.75, 7.15 ± 2.10, 16.28 ± 6.60, respectively). Moreover, serum 25(OH)D levels were significantly lower in the high HE grade than in the low grade (
P
< 0.001). Regarding the SBP group, classic SBP was associated with lower 25(OH)D levels compared to other types (
P
< 0.001). ROC curve revealed that lower 25(OH)D levels less than 7.1 ng/ml and 6.6 ng/ml could predict the mortality in SBP and HE patients, respectively, with high sensitivity and specificity. Serum 25(OH)D levels < 5 ng/ml were associated with significant higher mortality rate (HR = 2.76,
P
= 0.001). Lower 25(OH)D levels were associated with HE and SBP in cirrhotic patients. In addition, it may be considered a prognostic parameter for the severity of liver cirrhosis.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30706253</pmid><doi>10.1007/s11739-019-02042-2</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1095-1411</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1828-0447 |
| ispartof | Internal and emergency medicine, 2019-08, Vol.14 (5), p.753-761 |
| issn | 1828-0447 1970-9366 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2179511903 |
| source | MEDLINE; SpringerNature Journals |
| subjects | 25-Hydroxyvitamin D Aged Analysis of Variance Bacterial Infections - complications Bacterial Infections - physiopathology Cirrhosis Complications Egypt Female Hepacivirus - pathogenicity Hepacivirus - physiology Hepatic encephalopathy Hepatic Encephalopathy - blood Hepatic Encephalopathy - etiology Hepatic Encephalopathy - physiopathology Hepatitis Hepatitis C Humans Im - Original Internal Medicine Liver Liver cirrhosis Liver Cirrhosis - blood Liver Cirrhosis - etiology Liver Cirrhosis - physiopathology Male Medicine Medicine & Public Health Middle Aged Mortality Peritonitis Peritonitis - blood Peritonitis - etiology Peritonitis - physiopathology Prospective Studies Rank tests Regression analysis Risk Factors ROC Curve Statistical analysis Viruses Vitamin D Vitamin D - analysis Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D Deficiency - epidemiology Vitamin deficiency |
| title | Associated vitamin D deficiency is a risk factor for the complication of HCV-related liver cirrhosis including hepatic encephalopathy and spontaneous bacterial peritonitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T20%3A40%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Associated%20vitamin%20D%20deficiency%20is%20a%20risk%20factor%20for%20the%20complication%20of%20HCV-related%20liver%20cirrhosis%20including%20hepatic%20encephalopathy%20and%20spontaneous%20bacterial%20peritonitis&rft.jtitle=Internal%20and%20emergency%20medicine&rft.au=Yousif,%20Monkez%20Moteih&rft.date=2019-08-01&rft.volume=14&rft.issue=5&rft.spage=753&rft.epage=761&rft.pages=753-761&rft.issn=1828-0447&rft.eissn=1970-9366&rft_id=info:doi/10.1007/s11739-019-02042-2&rft_dat=%3Cproquest_cross%3E2174079719%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2174079719&rft_id=info:pmid/30706253&rfr_iscdi=true |