Cystic pancreatic neuroendocrine tumors: A more favorable lesion?
Pancreatic neuroendocrine tumors (PNETs) are predominantly solid lesions with malignant potential. Cystic PNETs are a small subset in which data are scarce. The aim of this study was to compare clinical and biologic differences between cystic and solid PNETs. Patients with PNETs undergoing pancreate...
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| Veröffentlicht in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2019-03, Vol.19 (2), p.372-376 |
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| container_title | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] |
| container_volume | 19 |
| creator | Carr, Rosalie A. Bletsis, Panagiotis Roch, Alexandra M. House, Michael G. Zyromski, Nicholas J. Nakeeb, Attila Schmidt, C. Max Ceppa, Eugene P. |
| description | Pancreatic neuroendocrine tumors (PNETs) are predominantly solid lesions with malignant potential. Cystic PNETs are a small subset in which data are scarce. The aim of this study was to compare clinical and biologic differences between cystic and solid PNETs.
Patients with PNETs undergoing pancreatectomy between 1988 and 2016 at a high-volume center were reviewed retrospectively. Demographic, clinical, and histopathologic data were collected and analyzed.
347 patients with PNETs were identified; 27% (n = 91) were cystic. Patients with cystic PNETs were generally older (59 vs. 55 years, p = 0.05). Cystic PNETs were more commonly non-functional (95% vs. 82%, p = 0.004), asymptomatic (44% vs. 28%, p = 0.009), and located in the pancreatic body/tail (81% vs. 60%, p |
| doi_str_mv | 10.1016/j.pan.2019.01.017 |
| format | Article |
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Patients with PNETs undergoing pancreatectomy between 1988 and 2016 at a high-volume center were reviewed retrospectively. Demographic, clinical, and histopathologic data were collected and analyzed.
347 patients with PNETs were identified; 27% (n = 91) were cystic. Patients with cystic PNETs were generally older (59 vs. 55 years, p = 0.05). Cystic PNETs were more commonly non-functional (95% vs. 82%, p = 0.004), asymptomatic (44% vs. 28%, p = 0.009), and located in the pancreatic body/tail (81% vs. 60%, p < 0.001) than solid PNETs. Although cystic and solid PNETs had similar sizes and pathologic stage at the time of resection, Ki-67 proliferation index (Ki-67 ≤ 9%: 98% vs. 85%; p = 0.007), and histologic grade (grade I: 84% vs. 59%; p = 0.009) had less aggressive features in cystic PNETs.
In addition to reporting a higher than previously published incidence of cystic PNET (27%), this study found significant differences in multiple clinicopathologic variables between cystic and solid PNETs. Cystic PNET may be a distinct and possibly less aggressive subtype of PNET yet have similar pathologic stage, recurrence, and survival to solid PNETs. Cystic PNETs require further attention to better understand the true natural history.</description><identifier>ISSN: 1424-3903</identifier><identifier>EISSN: 1424-3911</identifier><identifier>DOI: 10.1016/j.pan.2019.01.017</identifier><identifier>PMID: 30704851</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Cancer ; Classification ; Data processing ; Ki-67 ; Lymphatic system ; Medical prognosis ; Metastasis ; Neuroendocrine tumors ; Pancreas ; Pancreatic cancer ; Pancreatic cysts ; Pancreatic neuroendocrine tumors ; Pathology ; Patients ; Prognosis</subject><ispartof>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2019-03, Vol.19 (2), p.372-376</ispartof><rights>2019 IAP and EPC</rights><rights>Copyright © 2019 IAP and EPC. Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Limited Mar 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-9310aa46450e6bf7fb7313261fa1f755c88f1abfe56fd017e0ce0341263780bc3</citedby><cites>FETCH-LOGICAL-c447t-9310aa46450e6bf7fb7313261fa1f755c88f1abfe56fd017e0ce0341263780bc3</cites><orcidid>0000-0002-8368-2232</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30704851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carr, Rosalie A.</creatorcontrib><creatorcontrib>Bletsis, Panagiotis</creatorcontrib><creatorcontrib>Roch, Alexandra M.</creatorcontrib><creatorcontrib>House, Michael G.</creatorcontrib><creatorcontrib>Zyromski, Nicholas J.</creatorcontrib><creatorcontrib>Nakeeb, Attila</creatorcontrib><creatorcontrib>Schmidt, C. Max</creatorcontrib><creatorcontrib>Ceppa, Eugene P.</creatorcontrib><title>Cystic pancreatic neuroendocrine tumors: A more favorable lesion?</title><title>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</title><addtitle>Pancreatology</addtitle><description>Pancreatic neuroendocrine tumors (PNETs) are predominantly solid lesions with malignant potential. Cystic PNETs are a small subset in which data are scarce. The aim of this study was to compare clinical and biologic differences between cystic and solid PNETs.
Patients with PNETs undergoing pancreatectomy between 1988 and 2016 at a high-volume center were reviewed retrospectively. Demographic, clinical, and histopathologic data were collected and analyzed.
347 patients with PNETs were identified; 27% (n = 91) were cystic. Patients with cystic PNETs were generally older (59 vs. 55 years, p = 0.05). Cystic PNETs were more commonly non-functional (95% vs. 82%, p = 0.004), asymptomatic (44% vs. 28%, p = 0.009), and located in the pancreatic body/tail (81% vs. 60%, p < 0.001) than solid PNETs. Although cystic and solid PNETs had similar sizes and pathologic stage at the time of resection, Ki-67 proliferation index (Ki-67 ≤ 9%: 98% vs. 85%; p = 0.007), and histologic grade (grade I: 84% vs. 59%; p = 0.009) had less aggressive features in cystic PNETs.
In addition to reporting a higher than previously published incidence of cystic PNET (27%), this study found significant differences in multiple clinicopathologic variables between cystic and solid PNETs. Cystic PNET may be a distinct and possibly less aggressive subtype of PNET yet have similar pathologic stage, recurrence, and survival to solid PNETs. Cystic PNETs require further attention to better understand the true natural history.</description><subject>Cancer</subject><subject>Classification</subject><subject>Data processing</subject><subject>Ki-67</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Neuroendocrine tumors</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatic cysts</subject><subject>Pancreatic neuroendocrine tumors</subject><subject>Pathology</subject><subject>Patients</subject><subject>Prognosis</subject><issn>1424-3903</issn><issn>1424-3911</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMofv8AL1Lw4mXXmaRNtnqQZfELBC96Dmk6gSzdZk1awX9vllUPHoSBmcMzLzMPY2cIUwSUV8vp2vRTDlhPAXOpHXaIJS8nokbc_Z1BHLCjlJYAnCPW--xAgIJyVuEhmy8-0-BtkYNsJLMZexpjoL4NNvqeimFchZiui3mROxXOfIRomo6KjpIP_e0J23OmS3T63Y_Z2_3d6-Jx8vzy8LSYP09sWaphUgsEY0pZVkCycco1SqDgEp1Bp6rKzmYOTeOokq7NrxBYAlEil0LNoLHimF1uc9cxvI-UBr3yyVLXmZ7CmDRHVVeISvKMXvxBl2GMfb4uUzWAlMAxU7ilbAwpRXJ6Hf3KxE-NoDd-9VJnLXrjVwPmUnnn_Dt5bFbU_m78CM3AzRagrOLDU9TJeuottT6SHXQb_D_xXy29iUc</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Carr, Rosalie A.</creator><creator>Bletsis, Panagiotis</creator><creator>Roch, Alexandra M.</creator><creator>House, Michael G.</creator><creator>Zyromski, Nicholas J.</creator><creator>Nakeeb, Attila</creator><creator>Schmidt, C. Max</creator><creator>Ceppa, Eugene P.</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8368-2232</orcidid></search><sort><creationdate>201903</creationdate><title>Cystic pancreatic neuroendocrine tumors: A more favorable lesion?</title><author>Carr, Rosalie A. ; Bletsis, Panagiotis ; Roch, Alexandra M. ; House, Michael G. ; Zyromski, Nicholas J. ; Nakeeb, Attila ; Schmidt, C. 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Max</creatorcontrib><creatorcontrib>Ceppa, Eugene P.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carr, Rosalie A.</au><au>Bletsis, Panagiotis</au><au>Roch, Alexandra M.</au><au>House, Michael G.</au><au>Zyromski, Nicholas J.</au><au>Nakeeb, Attila</au><au>Schmidt, C. Max</au><au>Ceppa, Eugene P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cystic pancreatic neuroendocrine tumors: A more favorable lesion?</atitle><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle><addtitle>Pancreatology</addtitle><date>2019-03</date><risdate>2019</risdate><volume>19</volume><issue>2</issue><spage>372</spage><epage>376</epage><pages>372-376</pages><issn>1424-3903</issn><eissn>1424-3911</eissn><abstract>Pancreatic neuroendocrine tumors (PNETs) are predominantly solid lesions with malignant potential. Cystic PNETs are a small subset in which data are scarce. The aim of this study was to compare clinical and biologic differences between cystic and solid PNETs.
Patients with PNETs undergoing pancreatectomy between 1988 and 2016 at a high-volume center were reviewed retrospectively. Demographic, clinical, and histopathologic data were collected and analyzed.
347 patients with PNETs were identified; 27% (n = 91) were cystic. Patients with cystic PNETs were generally older (59 vs. 55 years, p = 0.05). Cystic PNETs were more commonly non-functional (95% vs. 82%, p = 0.004), asymptomatic (44% vs. 28%, p = 0.009), and located in the pancreatic body/tail (81% vs. 60%, p < 0.001) than solid PNETs. Although cystic and solid PNETs had similar sizes and pathologic stage at the time of resection, Ki-67 proliferation index (Ki-67 ≤ 9%: 98% vs. 85%; p = 0.007), and histologic grade (grade I: 84% vs. 59%; p = 0.009) had less aggressive features in cystic PNETs.
In addition to reporting a higher than previously published incidence of cystic PNET (27%), this study found significant differences in multiple clinicopathologic variables between cystic and solid PNETs. Cystic PNET may be a distinct and possibly less aggressive subtype of PNET yet have similar pathologic stage, recurrence, and survival to solid PNETs. Cystic PNETs require further attention to better understand the true natural history.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>30704851</pmid><doi>10.1016/j.pan.2019.01.017</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-8368-2232</orcidid></addata></record> |
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| ispartof | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2019-03, Vol.19 (2), p.372-376 |
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| source | Alma/SFX Local Collection |
| subjects | Cancer Classification Data processing Ki-67 Lymphatic system Medical prognosis Metastasis Neuroendocrine tumors Pancreas Pancreatic cancer Pancreatic cysts Pancreatic neuroendocrine tumors Pathology Patients Prognosis |
| title | Cystic pancreatic neuroendocrine tumors: A more favorable lesion? |
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