Exosomes derived from SDF1‐overexpressing mesenchymal stem cells inhibit ischemic myocardial cell apoptosis and promote cardiac endothelial microvascular regeneration in mice with myocardial infarction

Exosomes extracted from mesenchymal stem cells (MSCs) was reported to reduce myocardial ischemia/reperfusion damage. Besides, stromal‐derived factor 1 (SDF1a) functions as cardiac repair after myocardial infarction (MI). Therefore, the present study aims to identify whether exosomes (Exo) released f...

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Veröffentlicht in:	Journal of cellular physiology 2019-08, Vol.234 (8), p.13878-13893
Hauptverfasser:	Gong, Xu‐He, Liu, Hui, Wang, Si‐Jia, Liang, Si‐Wen, Wang, Guo‐Gan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Animals Apoptosis Autophagy Cardiac function Chemokine CXCL12 - metabolism Down-Regulation Endothelial cells Endothelial Cells - metabolism Endothelium, Vascular - pathology Exosomes Exosomes - metabolism Exosomes - ultrastructure Heart Heart attacks Heart Function Tests In vivo methods and tests Ischemia Male Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Mesenchyme Mice Mice, Inbred C57BL microvascular regeneration Microvasculature Microvessels - pathology Myocardial infarction Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - therapy Myocardial ischemia Myocardium - pathology Phagocytosis Phosphatidylinositol 3-Kinases - metabolism Regeneration Reperfusion SDF-1 protein Secretion Signal Transduction Signaling Sphingomyelin phosphodiesterase Stem cell transplantation Stem cells stromal cell‐derived factor 1
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