A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

A stable latent reservoir for HIV-1 in resting CD4 + T cells is the principal barrier to a cure 1 – 3 . Curative strategies that target the reservoir are being tested 4 , 5 and require accurate, scalable reservoir assays. The reservoir was defined with quantitative viral outgrowth assays for cells t...

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Veröffentlicht in:	Nature (London) 2019-02, Vol.566 (7742), p.120-125
Hauptverfasser:	Bruner, Katherine M., Wang, Zheng, Simonetti, Francesco R., Bender, Alexandra M., Kwon, Kyungyoon J., Sengupta, Srona, Fray, Emily J., Beg, Subul A., Antar, Annukka A. R., Jenike, Katharine M., Bertagnolli, Lynn N., Capoferri, Adam A., Kufera, Joshua T., Timmons, Andrew, Nobles, Christopher, Gregg, John, Wada, Nikolas, Ho, Ya-Chi, Zhang, Hao, Margolick, Joseph B., Blankson, Joel N., Deeks, Steven G., Bushman, Frederic D., Siliciano, Janet D., Laird, Gregory M., Siliciano, Robert F.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 45 45/23 45/77 631/326/596/2564 692/699/255/1901 Assaying Bioinformatics Carrier State - therapy Carrier State - virology CD4 antigen CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - virology Cell activation Cell Line Defective Viruses - genetics Defective Viruses - isolation & purification Defective Viruses - physiology Defects Deoxyribonucleic acid Distribution DNA DNA, Viral - analysis DNA, Viral - genetics Genomes HIV HIV infections HIV Infections - therapy HIV Infections - virology HIV tests HIV-1 - genetics HIV-1 - isolation & purification HIV-1 - physiology Human immunodeficiency virus Humanities and Social Sciences Humans Infections Letter Lymphocyte Activation Lymphocytes Lymphocytes T Medical schools Methods multidisciplinary Mutation Physiological aspects Polymerase Chain Reaction Proviruses Proviruses - genetics Proviruses - isolation & purification Proviruses - physiology Ribonucleic acid RNA Science Science (multidisciplinary) T cells Transcription Transcription (Genetics) Virus Latency Viruses
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