Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity

Lysosomes and mitochondria are both crucial cellular organelles for metabolic homeostasis and organism health. However, mechanisms linking their metabolic activities to promote organism longevity remain poorly understood. We discovered that the induction of specific lysosomal signaling mediated by a...

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Veröffentlicht in:	Developmental cell 2019-03, Vol.48 (5), p.685-696.e5
Hauptverfasser:	Ramachandran, Prasanna V., Savini, Marzia, Folick, Andrew K., Hu, Kuang, Masand, Ruchi, Graham, Brett H., Wang, Meng C.
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Animals Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - metabolism Escherichia coli - metabolism Homeostasis - physiology inter-organelle coordination longevity Longevity - physiology lysosomal signaling Lysosomes - metabolism metabolism Mitochondria - metabolism mitochondrial signaling Molecular Chaperones - metabolism Oxidative Stress Reactive Oxygen Species - metabolism redox homeostasis Transcription Factors
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