Crocin and voluntary exercise promote heart angiogenesis through Akt and ERK1/2 signalling in type 2 diabetic rats

signalling. Animals were divided into 4 groups as follows: diabetes (Dia), diabetic-crocin (Dia-Cro), diabetic-voluntary exercise (Dia-Exe), diabetic-crocin-voluntary exercise (Dia-Cro-Exe). Type 2 diabetes was induced by high-fat diet (4 weeks) and injection of streptozotocin (STZ) (i.p., 35 mg/kg)...

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Veröffentlicht in:	Bratislava Medical Journal 2018-01, Vol.119 (12), p.757-761
Hauptverfasser:	Dariushnejad, H, Mohammadi, M, Ghorbanzadeh, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carotenoids - pharmacology Diabetes Mellitus, Experimental Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - therapy MAP Kinase Signaling System - physiology Neovascularization, Physiologic - drug effects Physical Conditioning, Animal Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar
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container_end_page	761
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container_title	Bratislava Medical Journal
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creator	Dariushnejad, H Mohammadi, M Ghorbanzadeh, V
description	signalling. Animals were divided into 4 groups as follows: diabetes (Dia), diabetic-crocin (Dia-Cro), diabetic-voluntary exercise (Dia-Exe), diabetic-crocin-voluntary exercise (Dia-Cro-Exe). Type 2 diabetes was induced by high-fat diet (4 weeks) and injection of streptozotocin (STZ) (i.p., 35 mg/kg). Animals received crocin orally (50 mg/kg), voluntary exercise was performed alone or together with crocin for 8 weeks. Akt and ERK1/2 levels were measured by ELISA and CD31 was detected by immunohistochemistry. Akt and ERK1/2 levels in crocin and exercise groups were significantly higher than in diabetic group. Levels of Akt and ERK1/2 proteins and CD31 immunostaining were also significantly higher in crocin-voluntary exercise group in comparison to the other groups. Our results revealed that treatments with crocin and voluntary exercise had synergistic effect on angiogenesis. Protective effects of these interventions are probably through the activation of Akt and ERK 1/2 signalling pathways in the heart of diabetic rats (Fig. 3, Ref. 40).
doi_str_mv	10.4149/BLL_2018_138
format	Article
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Animals were divided into 4 groups as follows: diabetes (Dia), diabetic-crocin (Dia-Cro), diabetic-voluntary exercise (Dia-Exe), diabetic-crocin-voluntary exercise (Dia-Cro-Exe). Type 2 diabetes was induced by high-fat diet (4 weeks) and injection of streptozotocin (STZ) (i.p., 35 mg/kg). Animals received crocin orally (50 mg/kg), voluntary exercise was performed alone or together with crocin for 8 weeks. Akt and ERK1/2 levels were measured by ELISA and CD31 was detected by immunohistochemistry. Akt and ERK1/2 levels in crocin and exercise groups were significantly higher than in diabetic group. Levels of Akt and ERK1/2 proteins and CD31 immunostaining were also significantly higher in crocin-voluntary exercise group in comparison to the other groups. Our results revealed that treatments with crocin and voluntary exercise had synergistic effect on angiogenesis. 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subjects	Animals Carotenoids - pharmacology Diabetes Mellitus, Experimental Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - therapy MAP Kinase Signaling System - physiology Neovascularization, Physiologic - drug effects Physical Conditioning, Animal Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar
title	Crocin and voluntary exercise promote heart angiogenesis through Akt and ERK1/2 signalling in type 2 diabetic rats
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