Inhibition of activated factor X; a new pathway in ameliorating carbon tetrachloride–induced liver fibrosis in rats

Activated factor X has a central role in the coagulation activation and also contributes to chronic inflammation and tissue fibrosis. In this study, rivaroxaban, a direct factor X inhibitor, attenuates liver fibrosis induced by carbon tetrachloride (CCl4). Male rats were randomly allocated into thre...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2019-05, Vol.33 (5), p.e22287-n/a
Hauptverfasser:	Mahmoud, Nesreen Ishak, Messiha, Basim Anwar Shehata, Abo‐Saif, Ali Ahmed, Abdel‐Bakky, Mohamed Sadek
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Activated carbon Activation Anticoagulants Bile Carbon tetrachloride CCl4 CCL4 protein Coagulation Coagulation factors factor X Fibrin Fibrosis Growth factors Inflammation Liver liver fibrosis Muscles rivaroxaban Smooth muscle Tissue factor Tissues Transforming growth factor
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