Design, synthesis and biological evaluation of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide derivatives as novel P-glycoprotein inhibitors reversing multidrug resistance

[Display omitted] The overexpression of P-glycoprotein plays an important role in the process of multidrug resistance (MDR). P-gp inhibitors are one of the effective strategies to reverse tumor MDR. Novel P-gp inhibitors with phthalazinone scaffolds were designed, synthesized and evaluated. Compound...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic chemistry 2019-05, Vol.86, p.166-175
Hauptverfasser:	Qiu, Qianqian, Zhou, Jiaqi, Shi, Wei, Kairuki, Mutta, Huang, Wenglong, Qian, Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemical synthesis Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug Doxorubicin Doxorubicin - chemical synthesis Doxorubicin - chemistry Doxorubicin - pharmacology Drug Design Drug Resistance, Multiple - drug effects Drug Resistance, Neoplasm - drug effects Drug Screening Assays, Antitumor Humans Isoquinolines - chemical synthesis Isoquinolines - chemistry Isoquinolines - pharmacology K562 Cells Molecular Structure Multidrug resistance P-glycoprotein inhibitors Phthalazines - chemical synthesis Phthalazines - chemistry Phthalazines - pharmacology Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!