Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma

In medulloblastomas (MBs), the expression and activity of RE1-silencing transcription factor (REST) is increased in tumors driven by the sonic hedgehog (SHH) pathway, specifically the SHH-α (children 3 to 16 years) and SHH-β (infants) subgroups. Neuronal maturation is greater in SHH-β than SHH-α tum...

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Veröffentlicht in:	Science signaling 2019-01, Vol.12 (565)
Hauptverfasser:	Dobson, Tara H W, Tao, Rong-Hua, Swaminathan, Jyothishmathi, Maegawa, Shinji, Shaik, Shavali, Bravo-Alegria, Javiera, Sharma, Ajay, Kennis, Bridget, Yang, Yanwen, Callegari, Keri, Haltom, Amanda R, Taylor, Pete, Kogiso, Mari, Qi, Lin, Khatua, Soumen, Goldman, Stewart, Lulla, Rishi R, Fangusaro, Jason, MacDonald, Tobey J, Li, Xiao-Nan, Hawkins, Cynthia, Rajaram, Veena, Gopalakrishnan, Vidya
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adult AKT protein Animals Apoptosis Brain Brain tumors Cell Line, Tumor Cell proliferation Cerebellar Neoplasms - genetics Cerebellar Neoplasms - metabolism Cerebellar Neoplasms - pathology Cerebellum Child Children Chromatin - genetics Chromatin - metabolism Chromatin remodeling Disease Models, Animal Female Gene Expression Regulation, Neoplastic Gene silencing Hedgehog protein Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Humans Infant Infants Male Maturation Medulloblastoma Medulloblastoma - genetics Medulloblastoma - metabolism Medulloblastoma - pathology Methylation Mice, Inbred C57BL Mice, Inbred NOD Mice, Knockout Mice, SCID Mice, Transgenic Neoplasm Staging Neural stem cells Patched-1 Receptor - genetics Patched-1 Receptor - metabolism Patients Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism PTEN protein Repressor Proteins - genetics Repressor Proteins - metabolism Rest Rodents Signal transduction Signal Transduction - genetics Signaling Subgroups Therapeutic applications Transgenic mice Transplantation, Heterologous Tumorigenesis Tumors
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