Neurite-Enriched MicroRNA-218 Stimulates Translation of the GluA2 Subunit and Increases Excitatory Synaptic Strength

Local control of protein translation is a fundamental process for the regulation of synaptic plasticity. It has been demonstrated that the local protein synthesis occurring in axons and dendrites can be shaped by numerous mechanisms, including miRNA-mediated regulation. However, several aspects unde...

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Veröffentlicht in:	Molecular neurobiology 2019-08, Vol.56 (8), p.5701-5714
Hauptverfasser:	Rocchi, Anna, Moretti, Daniela, Lignani, Gabriele, Colombo, Elisabetta, Scholz-Starke, Joachim, Baldelli, Pietro, Tkatch, Tatiana, Benfenati, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biomedical and Life Sciences Biomedicine Cell Biology Cell Body - metabolism Dendrites Excitatory Postsynaptic Potentials Glutamatergic transmission Hippocampus Hippocampus - metabolism Homeostatic plasticity Mice, Inbred C57BL MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA mRNA Nerve Net - metabolism Neurites - metabolism Neurobiology Neurology Neurosciences Plasticity Protein Biosynthesis Protein Subunits - metabolism Protein synthesis Receptors, AMPA - metabolism Regulations Synapses - metabolism Synaptic plasticity Synaptic strength Synaptic transmission Translation α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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