Synergistic effect of bimodal pore distribution and artificial extracellular matrices in polymeric scaffolds on osteogenic differentiation of human mesenchymal stem cells

The main objective of this study was to enhance the biological performance of resorbable polymeric scaffolds for bone tissue engineering. Specifically, we focused on both microstructure and surface modification of the scaffolds to augment adhesion, proliferation and osteogenic differentiation of hum...

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Veröffentlicht in:	Materials Science & Engineering C 2019-04, Vol.97, p.12-22
Hauptverfasser:	Wojak-Ćwik, Iwona M., Rumian, Łucja, Krok-Borkowicz, Małgorzata, Hess, Ricarda, Bernhardt, Ricardo, Dobrzyński, Piotr, Möller, Stephanie, Schnabelrauch, Matthias, Hintze, Vera, Scharnweber, Dieter, Pamuła, Elżbieta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Artificial extracellular matrices Bimodal porosity Biocompatibility Biomedical materials Bone growth Bone sialoprotein Bone tissue engineering scaffolds Calcium Phosphates - metabolism Cell Adhesion Cell Differentiation - physiology Cell Proliferation Collagen Collagen (type I) Collagen Type I - chemistry Core Binding Factor Alpha 1 Subunit - metabolism Differentiation (biology) Extracellular Matrix Human mesenchymal stem cells Humans Hyaluronic acid Hyaluronic Acid - chemistry Integrin-Binding Sialoprotein - metabolism Leaching Male Materials science Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - physiology Mesenchyme Microscopy, Electron, Scanning Mineralization Osteogenesis Osteogenic differentiation Osteopontin Phase separation Poly(l‑lactide‑co‑glycolide) Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Polylactide-co-glycolide Regeneration Regeneration (physiology) Scaffolds Scanning electron microscopy Scanning transmission electron microscopy Stem cells Synergistic effect Tissue engineering Tissue Engineering - methods Tissue Scaffolds Toluidine Toluidine blue
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