C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition

Triple-negative breast cancer (TNBC) is an aggressive heterogeneous disease with a divergent profile. It has an earlier tendency to form metastases and is associated with poor clinical outcomes due to the limited treatment options available. Heat-shock protein (HSP90) represents a potential treatmen...

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Veröffentlicht in:	Cancer letters 2019-04, Vol.447, p.141-153
Hauptverfasser:	Cho, Tae-Min, Kim, Ji Young, Kim, Yoon-Jae, Sung, Daeil, Oh, Eunhye, Jang, Seojin, Farrand, Lee, Hoang, Van-Hai, Nguyen, Cong-Truong, Ann, Jihyae, Lee, Jeewoo, Seo, Jae Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Angiogenesis Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Breast cancer C-terminal HSP90 inhibitor Cancer stem cells Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cytotoxicity Female Flow cytometry Gene Expression Regulation, Neoplastic - drug effects HEK293 Cells HSP90 Heat-Shock Proteins - antagonists & inhibitors Hsp90 protein Humans Immunoglobulins Janus kinase 2 Kinases L80 Medical prognosis Metastases Metastasis Mice Mice, Inbred BALB C Neoplasm Metastasis - drug therapy Neovascularization, Pathologic - drug therapy Penicillin Proteins Signal transduction Signal Transduction - drug effects STAT3 Stat3 protein STAT3 Transcription Factor - antagonists & inhibitors Stem cells Therapeutic applications Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple-negative breast cancer Xenograft Model Antitumor Assays - methods
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