Cancer therapy with a CRISPR-assisted telomerase-activating gene expression system

Cancer is caused by a series of alterations in genome and epigenome and exists in multiple complex forms, making it difficult to be prevented and/or treated. Telomerase, an enzyme responsible for the maintenance of telomere, is silent in most normal somatic cells but activated in 90% of cancer cells...

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Veröffentlicht in:	Oncogene 2019-05, Vol.38 (21), p.4110-4124
Hauptverfasser:	Dai, Wei, Xu, Xinhui, Wang, Danyang, Wu, Jian, Wang, Jinke
Format:	Artikel
Sprache:	eng
Schlagworte:	42/109 42/44 631/67/1059/602 692/53 Analysis Animals Antineoplastic agents Apoptosis Biochemistry Bone marrow Cancer Cancer cells Cancer genetics Cancer research Cancer therapies Cancer treatment Cell Biology Cell Line Cell Line, Tumor Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR Dependovirus - genetics Endonuclease Enzymes Gene expression Gene Expression - genetics Gene Expression Regulation - genetics Gene therapy Genes Genetic engineering Genetic Therapy - methods Genetic vectors Genetic Vectors - genetics Genomes Genomics HEK293 Cells HeLa Cells Hep G2 Cells Human Genetics Humans Internal Medicine Intravenous administration Medicine Medicine & Public Health Mesenchymal Stem Cells - pathology Mesenchyme Mice Neoplasms - genetics Neoplasms - therapy Nucleases Oncology RAW 264.7 Cells Side effects Somatic cells Stem cells Telomerase Telomerase - genetics Telomere - genetics Telomeres Toxicity
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