Assessing bone impairment in ankylosing spondylitis (AS) using the trabecular bone score (TBS) and high-resolution peripheral quantitative computed tomography (HR-pQCT)
To compare bone quality using the trabecular bone score (TBS) and bone microarchitecture in the distal tibia using high-resolution peripheral quantitative computed tomography (HR-pQCT) in ankylosing spondylitis (AS) patients and healthy controls (HC). Areal bone mineral density (aBMD) and TBS (TBS i...
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2019-05, Vol.122, p.8-13 |
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| creator | Caparbo, Valeria F. Furlam, Pedro Saad, Carla G.S. Alvarenga, Jackeline C. Aubry-Rozier, Berengère Hans, Didier de Brum-Fernandes, Artur J. Pereira, Rosa M.R. |
| description | To compare bone quality using the trabecular bone score (TBS) and bone microarchitecture in the distal tibia using high-resolution peripheral quantitative computed tomography (HR-pQCT) in ankylosing spondylitis (AS) patients and healthy controls (HC).
Areal bone mineral density (aBMD) and TBS (TBS iNsight software) were evaluated using DXA (Hologic, QDR 4500); while volumetric bone mineral density (vBMD) and bone microarchitecture were analyzed in the distal tibia using HR-pQCT (Scanco) in 73 male patients with AS and 52 age-matched HC.
AS patients were a mean 41.6 ± 7.9 years old and had a mean disease duration of 16.4 ± 8.6 y, with a mean mSASSS 25.6 ± 16.4. No difference was observed in lumbar spine aBMD in AS patients and HC (p = 0.112), but total hip BMD (p = 0.011) and TBS (p |
| doi_str_mv | 10.1016/j.bone.2019.01.024 |
| format | Article |
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Areal bone mineral density (aBMD) and TBS (TBS iNsight software) were evaluated using DXA (Hologic, QDR 4500); while volumetric bone mineral density (vBMD) and bone microarchitecture were analyzed in the distal tibia using HR-pQCT (Scanco) in 73 male patients with AS and 52 age-matched HC.
AS patients were a mean 41.6 ± 7.9 years old and had a mean disease duration of 16.4 ± 8.6 y, with a mean mSASSS 25.6 ± 16.4. No difference was observed in lumbar spine aBMD in AS patients and HC (p = 0.112), but total hip BMD (p = 0.011) and TBS (p < 0.001) were lower in AS patients. In the distal tibia, reduced trabecular volumetric density [Tb.vBMD (p < 0.006)] and structural alterations — trabecular thickness (Tb.Th), p = 0.044 and trabecular separation (Tb.Sp), p = 0.039 — were observed in AS patients relative to controls. Further analysis comparing TBS < 1.310 and TBS ≥ 1.310 in AS patients revealed a higher mean body mass index [BMI] (p = 0.010), lower tibia cortical vBMD [Ct.vBMD] (p = 0.007), lower tibia cortical thickness [Ct.Th]: (p = 0.048) in the former group. On logistic regression analysis, BMI (OR = 1.27; 95%IC = 1.08–1.50, p = 0.005), (VF 4.65; 1.13–19.1, p = 0.033) and tibial Ct.vBMD (0.98; 0.97–1.00, p = 0.007) were associated with a lower TBS (<1.310).
The present study demonstrates that TBS and HR-pQCT imaging are important technologies evaluating bone impairment in AS patients. Moreover, in these patients vertebral fractures were associated with lower TBS.
•Trabecular bone score (TBS) is an essential DXA complement for the identification of bone impairment in ankylosing spondylitis (AS) patients.•TBS image will help rheumatologists to identify bone-quality deterioration in AS patients in routine clinical practice.•Body mass index, vertebral fractures and cortical volumetric BMD (using HR-pQCT) at tibia were associated with lower TBS in AS patients.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2019.01.024</identifier><identifier>PMID: 30708186</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Ankylosing spondylitis ; Bone density ; DXA ; HR-pQCT ; Trabecular bone score ; Vertebral fractures</subject><ispartof>Bone (New York, N.Y.), 2019-05, Vol.122, p.8-13</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-73f48b44ca435500a5c64bc5c8306f5849ce009839cb99ec617bf5770ba80cd03</citedby><cites>FETCH-LOGICAL-c356t-73f48b44ca435500a5c64bc5c8306f5849ce009839cb99ec617bf5770ba80cd03</cites><orcidid>0000-0002-3723-5028</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S8756328219300353$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30708186$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caparbo, Valeria F.</creatorcontrib><creatorcontrib>Furlam, Pedro</creatorcontrib><creatorcontrib>Saad, Carla G.S.</creatorcontrib><creatorcontrib>Alvarenga, Jackeline C.</creatorcontrib><creatorcontrib>Aubry-Rozier, Berengère</creatorcontrib><creatorcontrib>Hans, Didier</creatorcontrib><creatorcontrib>de Brum-Fernandes, Artur J.</creatorcontrib><creatorcontrib>Pereira, Rosa M.R.</creatorcontrib><title>Assessing bone impairment in ankylosing spondylitis (AS) using the trabecular bone score (TBS) and high-resolution peripheral quantitative computed tomography (HR-pQCT)</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>To compare bone quality using the trabecular bone score (TBS) and bone microarchitecture in the distal tibia using high-resolution peripheral quantitative computed tomography (HR-pQCT) in ankylosing spondylitis (AS) patients and healthy controls (HC).
Areal bone mineral density (aBMD) and TBS (TBS iNsight software) were evaluated using DXA (Hologic, QDR 4500); while volumetric bone mineral density (vBMD) and bone microarchitecture were analyzed in the distal tibia using HR-pQCT (Scanco) in 73 male patients with AS and 52 age-matched HC.
AS patients were a mean 41.6 ± 7.9 years old and had a mean disease duration of 16.4 ± 8.6 y, with a mean mSASSS 25.6 ± 16.4. No difference was observed in lumbar spine aBMD in AS patients and HC (p = 0.112), but total hip BMD (p = 0.011) and TBS (p < 0.001) were lower in AS patients. In the distal tibia, reduced trabecular volumetric density [Tb.vBMD (p < 0.006)] and structural alterations — trabecular thickness (Tb.Th), p = 0.044 and trabecular separation (Tb.Sp), p = 0.039 — were observed in AS patients relative to controls. Further analysis comparing TBS < 1.310 and TBS ≥ 1.310 in AS patients revealed a higher mean body mass index [BMI] (p = 0.010), lower tibia cortical vBMD [Ct.vBMD] (p = 0.007), lower tibia cortical thickness [Ct.Th]: (p = 0.048) in the former group. On logistic regression analysis, BMI (OR = 1.27; 95%IC = 1.08–1.50, p = 0.005), (VF 4.65; 1.13–19.1, p = 0.033) and tibial Ct.vBMD (0.98; 0.97–1.00, p = 0.007) were associated with a lower TBS (<1.310).
The present study demonstrates that TBS and HR-pQCT imaging are important technologies evaluating bone impairment in AS patients. Moreover, in these patients vertebral fractures were associated with lower TBS.
•Trabecular bone score (TBS) is an essential DXA complement for the identification of bone impairment in ankylosing spondylitis (AS) patients.•TBS image will help rheumatologists to identify bone-quality deterioration in AS patients in routine clinical practice.•Body mass index, vertebral fractures and cortical volumetric BMD (using HR-pQCT) at tibia were associated with lower TBS in AS patients.</description><subject>Ankylosing spondylitis</subject><subject>Bone density</subject><subject>DXA</subject><subject>HR-pQCT</subject><subject>Trabecular bone score</subject><subject>Vertebral fractures</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu1DAQhiMEokvhBTggH7eHhHGcxI7EZbuCtlIlBCxny3EmGy-JndpOpX0jHpNst3DkNNLMN5808yfJewoZBVp9PGSNs5jlQOsMaAZ58SJZUcFZmvOKvUxWgpdVynKRXyRvQjgAAKs5fZ1cMOAgqKhWye9NCBiCsXtykhEzTsr4EW0kxhJlfx0H9zQNk7PtcTDRBLLe_Lgi81M79kiiVw3qeVD-7AjaeSTr3fVCKduS3uz71GNwwxyNs2RCb6YevRrIw6xsNFFF84hEu3GaI7YkutHtvZr6I1nffk-nb9vd1dvkVaeGgO-e62Xy88vn3fY2vf96c7fd3KealVVMOesK0RSFVgUrSwBV6qpodKkFg6orRVFrBKgFq3VT16grypuu5BwaJUC3wC6T9dk7efcwY4hyNEHjMCiLbg4yp7wueJ1XbEHzM6q9C8FjJydvRuWPkoI8JSQP8vQQeUpIApVLQsvSh2f_3IzY_lv5G8kCfDoDuFz5aNDLoA1aja3xqKNsnfmf_w-8rKSd</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Caparbo, Valeria F.</creator><creator>Furlam, Pedro</creator><creator>Saad, Carla G.S.</creator><creator>Alvarenga, Jackeline C.</creator><creator>Aubry-Rozier, Berengère</creator><creator>Hans, Didier</creator><creator>de Brum-Fernandes, Artur J.</creator><creator>Pereira, Rosa M.R.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3723-5028</orcidid></search><sort><creationdate>201905</creationdate><title>Assessing bone impairment in ankylosing spondylitis (AS) using the trabecular bone score (TBS) and high-resolution peripheral quantitative computed tomography (HR-pQCT)</title><author>Caparbo, Valeria F. ; Furlam, Pedro ; Saad, Carla G.S. ; Alvarenga, Jackeline C. ; Aubry-Rozier, Berengère ; Hans, Didier ; de Brum-Fernandes, Artur J. ; Pereira, Rosa M.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-73f48b44ca435500a5c64bc5c8306f5849ce009839cb99ec617bf5770ba80cd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Ankylosing spondylitis</topic><topic>Bone density</topic><topic>DXA</topic><topic>HR-pQCT</topic><topic>Trabecular bone score</topic><topic>Vertebral fractures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caparbo, Valeria F.</creatorcontrib><creatorcontrib>Furlam, Pedro</creatorcontrib><creatorcontrib>Saad, Carla G.S.</creatorcontrib><creatorcontrib>Alvarenga, Jackeline C.</creatorcontrib><creatorcontrib>Aubry-Rozier, Berengère</creatorcontrib><creatorcontrib>Hans, Didier</creatorcontrib><creatorcontrib>de Brum-Fernandes, Artur J.</creatorcontrib><creatorcontrib>Pereira, Rosa M.R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caparbo, Valeria F.</au><au>Furlam, Pedro</au><au>Saad, Carla G.S.</au><au>Alvarenga, Jackeline C.</au><au>Aubry-Rozier, Berengère</au><au>Hans, Didier</au><au>de Brum-Fernandes, Artur J.</au><au>Pereira, Rosa M.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing bone impairment in ankylosing spondylitis (AS) using the trabecular bone score (TBS) and high-resolution peripheral quantitative computed tomography (HR-pQCT)</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2019-05</date><risdate>2019</risdate><volume>122</volume><spage>8</spage><epage>13</epage><pages>8-13</pages><issn>8756-3282</issn><eissn>1873-2763</eissn><abstract>To compare bone quality using the trabecular bone score (TBS) and bone microarchitecture in the distal tibia using high-resolution peripheral quantitative computed tomography (HR-pQCT) in ankylosing spondylitis (AS) patients and healthy controls (HC).
Areal bone mineral density (aBMD) and TBS (TBS iNsight software) were evaluated using DXA (Hologic, QDR 4500); while volumetric bone mineral density (vBMD) and bone microarchitecture were analyzed in the distal tibia using HR-pQCT (Scanco) in 73 male patients with AS and 52 age-matched HC.
AS patients were a mean 41.6 ± 7.9 years old and had a mean disease duration of 16.4 ± 8.6 y, with a mean mSASSS 25.6 ± 16.4. No difference was observed in lumbar spine aBMD in AS patients and HC (p = 0.112), but total hip BMD (p = 0.011) and TBS (p < 0.001) were lower in AS patients. In the distal tibia, reduced trabecular volumetric density [Tb.vBMD (p < 0.006)] and structural alterations — trabecular thickness (Tb.Th), p = 0.044 and trabecular separation (Tb.Sp), p = 0.039 — were observed in AS patients relative to controls. Further analysis comparing TBS < 1.310 and TBS ≥ 1.310 in AS patients revealed a higher mean body mass index [BMI] (p = 0.010), lower tibia cortical vBMD [Ct.vBMD] (p = 0.007), lower tibia cortical thickness [Ct.Th]: (p = 0.048) in the former group. On logistic regression analysis, BMI (OR = 1.27; 95%IC = 1.08–1.50, p = 0.005), (VF 4.65; 1.13–19.1, p = 0.033) and tibial Ct.vBMD (0.98; 0.97–1.00, p = 0.007) were associated with a lower TBS (<1.310).
The present study demonstrates that TBS and HR-pQCT imaging are important technologies evaluating bone impairment in AS patients. Moreover, in these patients vertebral fractures were associated with lower TBS.
•Trabecular bone score (TBS) is an essential DXA complement for the identification of bone impairment in ankylosing spondylitis (AS) patients.•TBS image will help rheumatologists to identify bone-quality deterioration in AS patients in routine clinical practice.•Body mass index, vertebral fractures and cortical volumetric BMD (using HR-pQCT) at tibia were associated with lower TBS in AS patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30708186</pmid><doi>10.1016/j.bone.2019.01.024</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3723-5028</orcidid></addata></record> |
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| subjects | Ankylosing spondylitis Bone density DXA HR-pQCT Trabecular bone score Vertebral fractures |
| title | Assessing bone impairment in ankylosing spondylitis (AS) using the trabecular bone score (TBS) and high-resolution peripheral quantitative computed tomography (HR-pQCT) |
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