Paricalcitol alleviates lipopolysaccharide-induced depressive-like behavior by suppressing hypothalamic microglia activation and neuroinflammation

[Display omitted] Depression is highly prevalent in patients suffering from chronic inflammatory diseases. Dysregulated neuroinflammation and concomitant activated microglia play a pivotal role in the pathogenesis of depression. Paricalcitol (Pari), a vitamin D2 analogue, has been demonstrated to ex...

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Veröffentlicht in:	Biochemical pharmacology 2019-05, Vol.163, p.1-8
Hauptverfasser:	He, Ming-chao, Shi, Zhe, Sha, Nan-nan, Chen, Nan, Peng, Shi-yu, Liao, Duan-fang, Wong, Man-sau, Dong, Xiao-li, Wang, Yong-jun, Yuan, Ti-fei, Zhang, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Depression - chemically induced Depression - drug therapy Depression - metabolism Depression-like behavior Ergocalciferols - pharmacology Ergocalciferols - therapeutic use Hypothalamus - drug effects Hypothalamus - metabolism Inflammation - drug therapy Inflammation - metabolism Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Lipopolysaccharides - toxicity LPS Male Mice Mice, Inbred C57BL Microglia - drug effects Microglia - metabolism Microgliosis Neuroinflammation Paricalcitol
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