Effect of Alprostadil on Colorectal Anastomoses Under Relative Ischemia

Anastomotic leak after colorectal surgery, which remains a serious clinical problem that causes augmented morbidity and mortality, is usually favored by ischemia. The aim of this study was to determine whether alprostadil may improve anastomotic wound healing under ischemic condition. Ninety-three a...

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Veröffentlicht in:	The Journal of surgical research 2019-04, Vol.236, p.230-237
Hauptverfasser:	Ruiz-Luque, Virgilio, Parra-Membrives, Pablo, Escudero-Severín, Carlos, Aguilar-Luque, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Alprostadil Alprostadil - administration & dosage Anastomosis, Surgical - adverse effects Anastomotic healing Anastomotic Leak - epidemiology Anastomotic Leak - etiology Anastomotic Leak - prevention & control Animals Colon - blood supply Colon - pathology Colon - surgery Colorectal anastomotic leakage Digestive System Surgical Procedures - adverse effects Disease Models, Animal Experimental study Humans Injections, Intraperitoneal Ischemia Ischemia - etiology Ischemia - surgery Male Random Allocation Rats Rats, Wistar Rectum - blood supply Rectum - pathology Rectum - surgery Surgical Wound Infection - epidemiology Surgical Wound Infection - etiology Surgical Wound Infection - prevention & control Tissue Adhesions - epidemiology Tissue Adhesions - etiology Tissue Adhesions - prevention & control Treatment Outcome Wound Healing - drug effects
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