Dried blood spot testing for estimation of renal function and analysis of metformin and sitagliptin concentrations in diabetic patients: a cross-sectional study
Purpose Dried blot spot (DBS) analysis of drugs or clinical parameters offers many advantages. We investigated the feasibility of using DBS for analysis of anti-diabetic drugs concomitantly with the estimated creatinine clearance (Cl crea ). Methods The cross-sectional study involved physicians in a...
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| Veröffentlicht in: | European journal of clinical pharmacology 2019-06, Vol.75 (6), p.809-816 |
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| creator | Scherf-Clavel, Maike Albert, Edwin Zieher, Stephan Valotis, Anagnostis Hickethier, Thomas Högger, Petra |
| description | Purpose
Dried blot spot (DBS) analysis of drugs or clinical parameters offers many advantages. We investigated the feasibility of using DBS for analysis of anti-diabetic drugs concomitantly with the estimated creatinine clearance (Cl
crea
).
Methods
The cross-sectional study involved physicians in an enabling analysis with 70 diabetic patients and community pharmacists in a field investigation with 84 participants. All 154 DBS samples were analyzed for creatinine, metformin, and sitagliptin.
Results
The diabetic patients revealed of a wide range of age (32–88 years), BMI values (19.8–54.7 kg/m
2
), and extent of polypharmacotherapy (1–21 drugs). A correlation factor to convert capillary blood creatinine from DBS into plasma concentrations was determined. Patients’ Cl
crea
ranged from 21.6–155.9 mL/min. The results indicated statistically significant correlations (
p
|
| doi_str_mv | 10.1007/s00228-019-02637-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179467468</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2174079649</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-31e0fea61455efa705722ecbdae8ff559f9f42d9010cc6ee88628dc8dccf62573</originalsourceid><addsrcrecordid>eNp9Uc1u1DAQthCILoUX4IAscenFMLYTO-GGSmmRKvVSzpHXGa9cJXGwHVX7Njwq3qSAxAHJlq35fsbjj5C3HD5wAP0xAQjRMOAtA6GkZo_PyI5XUjAOFX9OdgCSM9VqOCOvUnoA4HUL8iU5k6BBQVPvyM8v0WNP90MIPU1zyDRjyn46UBciPV1Hk32YaHA04mQG6pbJrhUz9WWb4Zh8OsEj5qIZ_YYkn81h8HPxojZMFqccV6dES6X3Zo_ZWzqXWoHSJ2qojSEllnC1L51SXvrja_LCmSHhm6fznHz_enV_ecNu766_XX6-ZVbqOjPJERwaxau6Rmc01FoItPveYONcXbeudZXoW-BgrUJsGiWa3pZlnRK1lufkYvOdY_ixlMG70SeLw2AmDEvqBNdtpXSlmkJ9_w_1ISyxvHhlVaBbVbWFJTbWOlZE182xfGY8dhy6U37dll9X8uvW_LrHInr3ZL3sR-z_SH4HVghyI6QCTQeMf3v_x_YXQ_yqoA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2174079649</pqid></control><display><type>article</type><title>Dried blood spot testing for estimation of renal function and analysis of metformin and sitagliptin concentrations in diabetic patients: a cross-sectional study</title><source>SpringerNature Journals</source><creator>Scherf-Clavel, Maike ; Albert, Edwin ; Zieher, Stephan ; Valotis, Anagnostis ; Hickethier, Thomas ; Högger, Petra</creator><creatorcontrib>Scherf-Clavel, Maike ; Albert, Edwin ; Zieher, Stephan ; Valotis, Anagnostis ; Hickethier, Thomas ; Högger, Petra</creatorcontrib><description>Purpose
Dried blot spot (DBS) analysis of drugs or clinical parameters offers many advantages. We investigated the feasibility of using DBS for analysis of anti-diabetic drugs concomitantly with the estimated creatinine clearance (Cl
crea
).
Methods
The cross-sectional study involved physicians in an enabling analysis with 70 diabetic patients and community pharmacists in a field investigation with 84 participants. All 154 DBS samples were analyzed for creatinine, metformin, and sitagliptin.
Results
The diabetic patients revealed of a wide range of age (32–88 years), BMI values (19.8–54.7 kg/m
2
), and extent of polypharmacotherapy (1–21 drugs). A correlation factor to convert capillary blood creatinine from DBS into plasma concentrations was determined. Patients’ Cl
crea
ranged from 21.6–155.9 mL/min. The results indicated statistically significant correlations (
p
< 0.05) between the use of two or three particular drug classes (diuretics, NSAIDs, renin-angiotensin system blockers) and a decreased renal function. DBS concentrations of metformin ranged between 0.23–4.99 μg/mL. The estimated elimination half-life (
t
½) of metformin was 11.9 h in patients with a Cl
Crea
higher than 60 mL/min and 18.5 h for diabetics with lower Cl
Crea
. Sitagliptin capillary blood concentrations ranged between 11.12–995.6 ng/mL. Calculated
t
½ of sitagliptin were 8.4 h and 13.0 h in patients with a Cl
Crea
above and below 60 mL/min, respectively.
Conclusions
DBS allow for the analysis of concentrations of predominantly renally eliminated drugs and community pharmacists can provide a valuable contribution to DBS sampling.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s00228-019-02637-w</identifier><identifier>PMID: 30706085</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Angiotensin ; Antidiabetics ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Body mass ; Correlation coefficients ; Creatinine ; Cross-sectional studies ; Diabetes ; Diabetes mellitus ; Diuretics ; Drugs ; Feasibility studies ; Field investigations ; Medical personnel ; Metformin ; Nonsteroidal anti-inflammatory drugs ; Pharmacokinetics and Disposition ; Pharmacology/Toxicology ; Radioactive half-life ; Renal function ; Renin ; Spot testing ; Statistical analysis</subject><ispartof>European journal of clinical pharmacology, 2019-06, Vol.75 (6), p.809-816</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>European Journal of Clinical Pharmacology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-31e0fea61455efa705722ecbdae8ff559f9f42d9010cc6ee88628dc8dccf62573</citedby><cites>FETCH-LOGICAL-c375t-31e0fea61455efa705722ecbdae8ff559f9f42d9010cc6ee88628dc8dccf62573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00228-019-02637-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00228-019-02637-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30706085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scherf-Clavel, Maike</creatorcontrib><creatorcontrib>Albert, Edwin</creatorcontrib><creatorcontrib>Zieher, Stephan</creatorcontrib><creatorcontrib>Valotis, Anagnostis</creatorcontrib><creatorcontrib>Hickethier, Thomas</creatorcontrib><creatorcontrib>Högger, Petra</creatorcontrib><title>Dried blood spot testing for estimation of renal function and analysis of metformin and sitagliptin concentrations in diabetic patients: a cross-sectional study</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><addtitle>Eur J Clin Pharmacol</addtitle><description>Purpose
Dried blot spot (DBS) analysis of drugs or clinical parameters offers many advantages. We investigated the feasibility of using DBS for analysis of anti-diabetic drugs concomitantly with the estimated creatinine clearance (Cl
crea
).
Methods
The cross-sectional study involved physicians in an enabling analysis with 70 diabetic patients and community pharmacists in a field investigation with 84 participants. All 154 DBS samples were analyzed for creatinine, metformin, and sitagliptin.
Results
The diabetic patients revealed of a wide range of age (32–88 years), BMI values (19.8–54.7 kg/m
2
), and extent of polypharmacotherapy (1–21 drugs). A correlation factor to convert capillary blood creatinine from DBS into plasma concentrations was determined. Patients’ Cl
crea
ranged from 21.6–155.9 mL/min. The results indicated statistically significant correlations (
p
< 0.05) between the use of two or three particular drug classes (diuretics, NSAIDs, renin-angiotensin system blockers) and a decreased renal function. DBS concentrations of metformin ranged between 0.23–4.99 μg/mL. The estimated elimination half-life (
t
½) of metformin was 11.9 h in patients with a Cl
Crea
higher than 60 mL/min and 18.5 h for diabetics with lower Cl
Crea
. Sitagliptin capillary blood concentrations ranged between 11.12–995.6 ng/mL. Calculated
t
½ of sitagliptin were 8.4 h and 13.0 h in patients with a Cl
Crea
above and below 60 mL/min, respectively.
Conclusions
DBS allow for the analysis of concentrations of predominantly renally eliminated drugs and community pharmacists can provide a valuable contribution to DBS sampling.</description><subject>Angiotensin</subject><subject>Antidiabetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Body mass</subject><subject>Correlation coefficients</subject><subject>Creatinine</subject><subject>Cross-sectional studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diuretics</subject><subject>Drugs</subject><subject>Feasibility studies</subject><subject>Field investigations</subject><subject>Medical personnel</subject><subject>Metformin</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Pharmacokinetics and Disposition</subject><subject>Pharmacology/Toxicology</subject><subject>Radioactive half-life</subject><subject>Renal function</subject><subject>Renin</subject><subject>Spot testing</subject><subject>Statistical analysis</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9Uc1u1DAQthCILoUX4IAscenFMLYTO-GGSmmRKvVSzpHXGa9cJXGwHVX7Njwq3qSAxAHJlq35fsbjj5C3HD5wAP0xAQjRMOAtA6GkZo_PyI5XUjAOFX9OdgCSM9VqOCOvUnoA4HUL8iU5k6BBQVPvyM8v0WNP90MIPU1zyDRjyn46UBciPV1Hk32YaHA04mQG6pbJrhUz9WWb4Zh8OsEj5qIZ_YYkn81h8HPxojZMFqccV6dES6X3Zo_ZWzqXWoHSJ2qojSEllnC1L51SXvrja_LCmSHhm6fznHz_enV_ecNu766_XX6-ZVbqOjPJERwaxau6Rmc01FoItPveYONcXbeudZXoW-BgrUJsGiWa3pZlnRK1lufkYvOdY_ixlMG70SeLw2AmDEvqBNdtpXSlmkJ9_w_1ISyxvHhlVaBbVbWFJTbWOlZE182xfGY8dhy6U37dll9X8uvW_LrHInr3ZL3sR-z_SH4HVghyI6QCTQeMf3v_x_YXQ_yqoA</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Scherf-Clavel, Maike</creator><creator>Albert, Edwin</creator><creator>Zieher, Stephan</creator><creator>Valotis, Anagnostis</creator><creator>Hickethier, Thomas</creator><creator>Högger, Petra</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>Dried blood spot testing for estimation of renal function and analysis of metformin and sitagliptin concentrations in diabetic patients: a cross-sectional study</title><author>Scherf-Clavel, Maike ; Albert, Edwin ; Zieher, Stephan ; Valotis, Anagnostis ; Hickethier, Thomas ; Högger, Petra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-31e0fea61455efa705722ecbdae8ff559f9f42d9010cc6ee88628dc8dccf62573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Angiotensin</topic><topic>Antidiabetics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood</topic><topic>Body mass</topic><topic>Correlation coefficients</topic><topic>Creatinine</topic><topic>Cross-sectional studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diuretics</topic><topic>Drugs</topic><topic>Feasibility studies</topic><topic>Field investigations</topic><topic>Medical personnel</topic><topic>Metformin</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Pharmacokinetics and Disposition</topic><topic>Pharmacology/Toxicology</topic><topic>Radioactive half-life</topic><topic>Renal function</topic><topic>Renin</topic><topic>Spot testing</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scherf-Clavel, Maike</creatorcontrib><creatorcontrib>Albert, Edwin</creatorcontrib><creatorcontrib>Zieher, Stephan</creatorcontrib><creatorcontrib>Valotis, Anagnostis</creatorcontrib><creatorcontrib>Hickethier, Thomas</creatorcontrib><creatorcontrib>Högger, Petra</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scherf-Clavel, Maike</au><au>Albert, Edwin</au><au>Zieher, Stephan</au><au>Valotis, Anagnostis</au><au>Hickethier, Thomas</au><au>Högger, Petra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dried blood spot testing for estimation of renal function and analysis of metformin and sitagliptin concentrations in diabetic patients: a cross-sectional study</atitle><jtitle>European journal of clinical pharmacology</jtitle><stitle>Eur J Clin Pharmacol</stitle><addtitle>Eur J Clin Pharmacol</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>75</volume><issue>6</issue><spage>809</spage><epage>816</epage><pages>809-816</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Purpose
Dried blot spot (DBS) analysis of drugs or clinical parameters offers many advantages. We investigated the feasibility of using DBS for analysis of anti-diabetic drugs concomitantly with the estimated creatinine clearance (Cl
crea
).
Methods
The cross-sectional study involved physicians in an enabling analysis with 70 diabetic patients and community pharmacists in a field investigation with 84 participants. All 154 DBS samples were analyzed for creatinine, metformin, and sitagliptin.
Results
The diabetic patients revealed of a wide range of age (32–88 years), BMI values (19.8–54.7 kg/m
2
), and extent of polypharmacotherapy (1–21 drugs). A correlation factor to convert capillary blood creatinine from DBS into plasma concentrations was determined. Patients’ Cl
crea
ranged from 21.6–155.9 mL/min. The results indicated statistically significant correlations (
p
< 0.05) between the use of two or three particular drug classes (diuretics, NSAIDs, renin-angiotensin system blockers) and a decreased renal function. DBS concentrations of metformin ranged between 0.23–4.99 μg/mL. The estimated elimination half-life (
t
½) of metformin was 11.9 h in patients with a Cl
Crea
higher than 60 mL/min and 18.5 h for diabetics with lower Cl
Crea
. Sitagliptin capillary blood concentrations ranged between 11.12–995.6 ng/mL. Calculated
t
½ of sitagliptin were 8.4 h and 13.0 h in patients with a Cl
Crea
above and below 60 mL/min, respectively.
Conclusions
DBS allow for the analysis of concentrations of predominantly renally eliminated drugs and community pharmacists can provide a valuable contribution to DBS sampling.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30706085</pmid><doi>10.1007/s00228-019-02637-w</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of clinical pharmacology, 2019-06, Vol.75 (6), p.809-816 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| source | SpringerNature Journals |
| subjects | Angiotensin Antidiabetics Biomedical and Life Sciences Biomedicine Blood Body mass Correlation coefficients Creatinine Cross-sectional studies Diabetes Diabetes mellitus Diuretics Drugs Feasibility studies Field investigations Medical personnel Metformin Nonsteroidal anti-inflammatory drugs Pharmacokinetics and Disposition Pharmacology/Toxicology Radioactive half-life Renal function Renin Spot testing Statistical analysis |
| title | Dried blood spot testing for estimation of renal function and analysis of metformin and sitagliptin concentrations in diabetic patients: a cross-sectional study |
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