Dried blood spot testing for estimation of renal function and analysis of metformin and sitagliptin concentrations in diabetic patients: a cross-sectional study
Purpose Dried blot spot (DBS) analysis of drugs or clinical parameters offers many advantages. We investigated the feasibility of using DBS for analysis of anti-diabetic drugs concomitantly with the estimated creatinine clearance (Cl crea ). Methods The cross-sectional study involved physicians in a...
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Veröffentlicht in: | European journal of clinical pharmacology 2019-06, Vol.75 (6), p.809-816 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Purpose
Dried blot spot (DBS) analysis of drugs or clinical parameters offers many advantages. We investigated the feasibility of using DBS for analysis of anti-diabetic drugs concomitantly with the estimated creatinine clearance (Cl
crea
).
Methods
The cross-sectional study involved physicians in an enabling analysis with 70 diabetic patients and community pharmacists in a field investigation with 84 participants. All 154 DBS samples were analyzed for creatinine, metformin, and sitagliptin.
Results
The diabetic patients revealed of a wide range of age (32–88 years), BMI values (19.8–54.7 kg/m
2
), and extent of polypharmacotherapy (1–21 drugs). A correlation factor to convert capillary blood creatinine from DBS into plasma concentrations was determined. Patients’ Cl
crea
ranged from 21.6–155.9 mL/min. The results indicated statistically significant correlations (
p
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ISSN: | 0031-6970 1432-1041 |
DOI: | 10.1007/s00228-019-02637-w |