Dried blood spot testing for estimation of renal function and analysis of metformin and sitagliptin concentrations in diabetic patients: a cross-sectional study

Purpose Dried blot spot (DBS) analysis of drugs or clinical parameters offers many advantages. We investigated the feasibility of using DBS for analysis of anti-diabetic drugs concomitantly with the estimated creatinine clearance (Cl crea ). Methods The cross-sectional study involved physicians in a...

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Veröffentlicht in:European journal of clinical pharmacology 2019-06, Vol.75 (6), p.809-816
Hauptverfasser: Scherf-Clavel, Maike, Albert, Edwin, Zieher, Stephan, Valotis, Anagnostis, Hickethier, Thomas, Högger, Petra
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Sprache:eng
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Zusammenfassung:Purpose Dried blot spot (DBS) analysis of drugs or clinical parameters offers many advantages. We investigated the feasibility of using DBS for analysis of anti-diabetic drugs concomitantly with the estimated creatinine clearance (Cl crea ). Methods The cross-sectional study involved physicians in an enabling analysis with 70 diabetic patients and community pharmacists in a field investigation with 84 participants. All 154 DBS samples were analyzed for creatinine, metformin, and sitagliptin. Results The diabetic patients revealed of a wide range of age (32–88 years), BMI values (19.8–54.7 kg/m 2 ), and extent of polypharmacotherapy (1–21 drugs). A correlation factor to convert capillary blood creatinine from DBS into plasma concentrations was determined. Patients’ Cl crea ranged from 21.6–155.9 mL/min. The results indicated statistically significant correlations ( p  
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-019-02637-w