Involvement of Aryl Hydrocarbon Receptor in l-Kynurenine-Mediated Parathyroid Hormone–Related Peptide Expression

Parathyroid hormone-related peptide (PTHrP), produced by specific cancers such as lung cancer, profoundly influences the formation of bone metastatic lesions via the “vicious cycle” of tumor growth and bone resorption. The changes in gene expression regulated by the abnormal microenvironment compone...

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Veröffentlicht in:	Discover. Oncology 2019-06, Vol.10 (2-3), p.89-96
Hauptverfasser:	Duan, Zhiqing, Lu, Jiangong
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Basic Helix-Loop-Helix Transcription Factors - metabolism Bone Neoplasms - secondary Cell Biology Cell Line, Tumor Cell Movement Dioxins Endocrinology Gene expression Humans Hydrocarbons Internal Medicine Kynurenine - metabolism Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical prognosis Medicine Medicine & Public Health Metastasis Microbiology Neoplasm Metastasis Oncology Original Paper Parathyroid Hormone-Related Protein - metabolism Peptides Physiology Prostate Protein expression Proteins Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism RNA, Small Interfering - metabolism Systems Biology Tumor Microenvironment Tumors Up-Regulation
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