INCLUSION OF SITE-SPECIFIC MUTATIONS INTO CONSERVATIVE SEG- MENTS OF PA-GENE RESULTS IN ATTENUATION OF VIRULENT INFLUENZA VIRUS STRAIN A/WSN/33

Study the possibility of obtaining attenuated variants of influenza virus by including specially selected site-specific mutations into a conservative sequence of PA-gene (terminal segment of COOH-domain of the PA-gene) of a virulent strain. A/ WSN/33 - a virulent strain of influenza virus was used i...

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Veröffentlicht in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii ėpidemiologii i immunobiologii, 2017-03 (2), p.45-53
Hauptverfasser:	Rtischev, A A, Mintaev, R R, Kost, V Yu, Koptyaeva, L B, Akopova, I I, Lisovskaya, K V, Markushin, S G
Format:	Artikel
Sprache:	eng ; rus
Online-Zugang:	Volltext
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