Eltrombopag treatment during induction chemotherapy for acute myeloid leukaemia: a randomised, double-blind, phase 2 study

Patients with acute myeloid leukaemia frequently have thrombocytopenia during induction chemotherapy. Eltrombopag, an oral thrombopoietin receptor agonist, stimulates platelet production by a similar mechanism to endogenous thrombopoietin. This study investigated safety and efficacy of eltrombopag v...

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Veröffentlicht in:	The Lancet. Haematology 2019-03, Vol.6 (3), p.e122-e131
Hauptverfasser:	Frey, Noelle, Jang, Jun Ho, Szer, Jeff, Illés, Árpád, Kim, Hee-Je, Ram, Ron, Chong, Beng H, Rowe, Jacob M, Borisenkova, Elena, Liesveld, Jane, Winer, Eric S, Cherfi, Azzeddine, Aslanis, Vassilios, Ghaznawi, Farhat, Strickland, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Benzoates - pharmacology Benzoates - therapeutic use Daunorubicin - pharmacokinetics Double-Blind Method Drug Interactions Female Humans Hydrazines - pharmacology Hydrazines - therapeutic use Induction Chemotherapy Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Male Middle Aged Pyrazoles - pharmacology Pyrazoles - therapeutic use Young Adult
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