Exploring Cerebrospinal Fluid IgG N-Glycosylation as Potential Biomarker for Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which the existing candidate biomarkers (neurofilaments) have low specificity. Changes in blood IgG N -glycosylation have been observed in several diseases, including ALS, whereas cerebrospinal fluid (CSF) IgG has been less stud...

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Veröffentlicht in:	Molecular neurobiology 2019-08, Vol.56 (8), p.5729-5739
Hauptverfasser:	Costa, Julia, Streich, Linda, Pinto, Susana, Pronto-Laborinho, Ana, Nimtz, Manfred, Conradt, Harald S., de Carvalho, Mamede
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - cerebrospinal fluid Biomarkers Biomarkers - cerebrospinal fluid Biomedical and Life Sciences Biomedicine Cell Biology Cerebrospinal fluid Female Fucose Glycoside Hydrolases - metabolism Glycosylation High-performance liquid chromatography Humans Immunoglobulin G Immunoglobulin G - cerebrospinal fluid Liquid chromatography Male Mass spectrometry Mass spectroscopy Middle Aged Motor neuron diseases N-glycans N-glycosidase Neurobiology Neurofilaments Neurological diseases Neurology Neurosciences ortho-Aminobenzoates - metabolism Polysaccharides Polysaccharides - metabolism
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