Resistin-Inhibited Neural Stem Cell-Derived Astrocyte Differentiation Contributes to Permeability Destruction of the Blood–Brain Barrier
Neuroinflammation is an important part of the development of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s and amyotrophic lateral sclerosis. Inflammatory factors destroy the balance of the microenvironment, which results in changes in neural stem cell differentiation and...
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| Veröffentlicht in: | Neurochemical research 2019-04, Vol.44 (4), p.905-916 |
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| creator | Xiaoying, Liu Li, Tian Yu, Shang Jiusheng, Jiang Jilin, Zhang Jiayi, Wei Dongxin, Liu Wengang, Fang Xinyue, Zhao Hao, Yu Yuhua, Chen Deshu, Shang |
| description | Neuroinflammation is an important part of the development of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s and amyotrophic lateral sclerosis. Inflammatory factors destroy the balance of the microenvironment, which results in changes in neural stem cell differentiation and proliferation behaviour. However, the mechanism underlying inflammatory factor-induced NSC behavioural changes is not clear. Resistin is a proinflammatory and adipogenic factor and is involved in several human pathology processes. The neural stem cell microenvironment changes when the concentration of resistin in the brain during an inflammatory response disease increases. In the present study, we explored the effect and mechanism of resistin on the proliferation and differentiation of neural stem cells. We found that intracerebroventricular injection of resistin induced a decrease in GFAP-positive cells in mice by influencing NSC differentiation. Resistin significantly decreased TEER and increased permeability in an in vitro blood–brain barrier model, which is consistent with the results of an HBMEC-astrocyte coculture system. Resistin-inhibited astrocyte differentiation is mediated through TLR4 on neural stem cells. To our knowledge, this is the first study reporting the effect of resistin on neural stem cells. Our findings shed light on resistin-involved neural stem cell degeneration mechanisms. |
| doi_str_mv | 10.1007/s11064-019-02726-3 |
| format | Article |
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Inflammatory factors destroy the balance of the microenvironment, which results in changes in neural stem cell differentiation and proliferation behaviour. However, the mechanism underlying inflammatory factor-induced NSC behavioural changes is not clear. Resistin is a proinflammatory and adipogenic factor and is involved in several human pathology processes. The neural stem cell microenvironment changes when the concentration of resistin in the brain during an inflammatory response disease increases. In the present study, we explored the effect and mechanism of resistin on the proliferation and differentiation of neural stem cells. We found that intracerebroventricular injection of resistin induced a decrease in GFAP-positive cells in mice by influencing NSC differentiation. Resistin significantly decreased TEER and increased permeability in an in vitro blood–brain barrier model, which is consistent with the results of an HBMEC-astrocyte coculture system. Resistin-inhibited astrocyte differentiation is mediated through TLR4 on neural stem cells. To our knowledge, this is the first study reporting the effect of resistin on neural stem cells. Our findings shed light on resistin-involved neural stem cell degeneration mechanisms.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-019-02726-3</identifier><identifier>PMID: 30690681</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alzheimer's disease ; Amyotrophic lateral sclerosis ; Animals ; Astrocytes - drug effects ; Astrocytes - metabolism ; Astrocytes - pathology ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Blood-Brain Barrier - drug effects ; Blood-Brain Barrier - metabolism ; Blood-Brain Barrier - pathology ; Brain ; Capillary Permeability - drug effects ; Capillary Permeability - physiology ; Cell Biology ; Cell differentiation ; Cell Differentiation - drug effects ; Cell Differentiation - physiology ; Cell proliferation ; Degeneration ; Differentiation (biology) ; Dose-Response Relationship, Drug ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - pathology ; Glial fibrillary acidic protein ; Human pathology ; Humans ; Inflammatory response ; Injections, Intraventricular ; Male ; Mice ; Mice, Inbred C57BL ; Neural stem cells ; Neural Stem Cells - drug effects ; Neural Stem Cells - metabolism ; Neural Stem Cells - pathology ; Neurochemistry ; Neurodegeneration ; Neurodegenerative diseases ; Neurogenesis - drug effects ; Neurogenesis - physiology ; Neurological diseases ; Neurology ; Neurosciences ; Original Paper ; Permeability ; Resistin - administration & dosage ; Resistin - toxicity ; Stem cell transplantation ; Stem cells ; TLR4 protein ; Toll-like receptors</subject><ispartof>Neurochemical research, 2019-04, Vol.44 (4), p.905-916</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Neurochemical Research is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-1c0a3139362344371fdfb75b0d6a9bf03d7065391083843b36a63ab8fb3bcd073</citedby><cites>FETCH-LOGICAL-c375t-1c0a3139362344371fdfb75b0d6a9bf03d7065391083843b36a63ab8fb3bcd073</cites><orcidid>0000-0001-5011-3431</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-019-02726-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-019-02726-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30690681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiaoying, Liu</creatorcontrib><creatorcontrib>Li, Tian</creatorcontrib><creatorcontrib>Yu, Shang</creatorcontrib><creatorcontrib>Jiusheng, Jiang</creatorcontrib><creatorcontrib>Jilin, Zhang</creatorcontrib><creatorcontrib>Jiayi, Wei</creatorcontrib><creatorcontrib>Dongxin, Liu</creatorcontrib><creatorcontrib>Wengang, Fang</creatorcontrib><creatorcontrib>Xinyue, Zhao</creatorcontrib><creatorcontrib>Hao, Yu</creatorcontrib><creatorcontrib>Yuhua, Chen</creatorcontrib><creatorcontrib>Deshu, Shang</creatorcontrib><title>Resistin-Inhibited Neural Stem Cell-Derived Astrocyte Differentiation Contributes to Permeability Destruction of the Blood–Brain Barrier</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>Neuroinflammation is an important part of the development of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s and amyotrophic lateral sclerosis. Inflammatory factors destroy the balance of the microenvironment, which results in changes in neural stem cell differentiation and proliferation behaviour. However, the mechanism underlying inflammatory factor-induced NSC behavioural changes is not clear. Resistin is a proinflammatory and adipogenic factor and is involved in several human pathology processes. The neural stem cell microenvironment changes when the concentration of resistin in the brain during an inflammatory response disease increases. In the present study, we explored the effect and mechanism of resistin on the proliferation and differentiation of neural stem cells. We found that intracerebroventricular injection of resistin induced a decrease in GFAP-positive cells in mice by influencing NSC differentiation. Resistin significantly decreased TEER and increased permeability in an in vitro blood–brain barrier model, which is consistent with the results of an HBMEC-astrocyte coculture system. Resistin-inhibited astrocyte differentiation is mediated through TLR4 on neural stem cells. To our knowledge, this is the first study reporting the effect of resistin on neural stem cells. Our findings shed light on resistin-involved neural stem cell degeneration mechanisms.</description><subject>Alzheimer's disease</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Animals</subject><subject>Astrocytes - drug effects</subject><subject>Astrocytes - metabolism</subject><subject>Astrocytes - pathology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Blood-Brain Barrier - metabolism</subject><subject>Blood-Brain Barrier - pathology</subject><subject>Brain</subject><subject>Capillary Permeability - drug effects</subject><subject>Capillary Permeability - physiology</subject><subject>Cell Biology</subject><subject>Cell differentiation</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - physiology</subject><subject>Cell proliferation</subject><subject>Degeneration</subject><subject>Differentiation (biology)</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - pathology</subject><subject>Glial fibrillary acidic protein</subject><subject>Human pathology</subject><subject>Humans</subject><subject>Inflammatory response</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neural stem cells</subject><subject>Neural Stem Cells - drug effects</subject><subject>Neural Stem Cells - metabolism</subject><subject>Neural Stem Cells - pathology</subject><subject>Neurochemistry</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neurogenesis - drug effects</subject><subject>Neurogenesis - physiology</subject><subject>Neurological diseases</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Permeability</subject><subject>Resistin - administration & dosage</subject><subject>Resistin - 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Academic</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiaoying, Liu</au><au>Li, Tian</au><au>Yu, Shang</au><au>Jiusheng, Jiang</au><au>Jilin, Zhang</au><au>Jiayi, Wei</au><au>Dongxin, Liu</au><au>Wengang, Fang</au><au>Xinyue, Zhao</au><au>Hao, Yu</au><au>Yuhua, Chen</au><au>Deshu, Shang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistin-Inhibited Neural Stem Cell-Derived Astrocyte Differentiation Contributes to Permeability Destruction of the Blood–Brain Barrier</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>44</volume><issue>4</issue><spage>905</spage><epage>916</epage><pages>905-916</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Neuroinflammation is an important part of the development of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s and amyotrophic lateral sclerosis. Inflammatory factors destroy the balance of the microenvironment, which results in changes in neural stem cell differentiation and proliferation behaviour. However, the mechanism underlying inflammatory factor-induced NSC behavioural changes is not clear. Resistin is a proinflammatory and adipogenic factor and is involved in several human pathology processes. The neural stem cell microenvironment changes when the concentration of resistin in the brain during an inflammatory response disease increases. In the present study, we explored the effect and mechanism of resistin on the proliferation and differentiation of neural stem cells. We found that intracerebroventricular injection of resistin induced a decrease in GFAP-positive cells in mice by influencing NSC differentiation. Resistin significantly decreased TEER and increased permeability in an in vitro blood–brain barrier model, which is consistent with the results of an HBMEC-astrocyte coculture system. Resistin-inhibited astrocyte differentiation is mediated through TLR4 on neural stem cells. To our knowledge, this is the first study reporting the effect of resistin on neural stem cells. Our findings shed light on resistin-involved neural stem cell degeneration mechanisms.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30690681</pmid><doi>10.1007/s11064-019-02726-3</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5011-3431</orcidid></addata></record> |
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| subjects | Alzheimer's disease Amyotrophic lateral sclerosis Animals Astrocytes - drug effects Astrocytes - metabolism Astrocytes - pathology Biochemistry Biomedical and Life Sciences Biomedicine Blood Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain Capillary Permeability - drug effects Capillary Permeability - physiology Cell Biology Cell differentiation Cell Differentiation - drug effects Cell Differentiation - physiology Cell proliferation Degeneration Differentiation (biology) Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Glial fibrillary acidic protein Human pathology Humans Inflammatory response Injections, Intraventricular Male Mice Mice, Inbred C57BL Neural stem cells Neural Stem Cells - drug effects Neural Stem Cells - metabolism Neural Stem Cells - pathology Neurochemistry Neurodegeneration Neurodegenerative diseases Neurogenesis - drug effects Neurogenesis - physiology Neurological diseases Neurology Neurosciences Original Paper Permeability Resistin - administration & dosage Resistin - toxicity Stem cell transplantation Stem cells TLR4 protein Toll-like receptors |
| title | Resistin-Inhibited Neural Stem Cell-Derived Astrocyte Differentiation Contributes to Permeability Destruction of the Blood–Brain Barrier |
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