Microglia and brain angiotensin type 1 receptors are involved in desensitising baroreflex by intracerebroventricular hypertonic saline in male Sprague-Dawley rats

High salt diet alters cardiovascular control by increasing concentration of sodium ions (Na+) in cerebrospinal fluid (CSF) and is a risk factor for hypertension. Hypernatremic conditions activate microglia and upregulate renin-angiotensin system in the brain. Thus, we checked if chronic elevation of...

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Veröffentlicht in:	Autonomic neuroscience 2019-03, Vol.217, p.49-57
Hauptverfasser:	Żera, Tymoteusz, Nowiński, Artur, Segiet, Agnieszka, Smykiewicz, Paweł
Format:	Artikel
Sprache:	eng
Schlagworte:	Air jet stress Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensin type 1 receptor (AT1R) Animals Baroreflex Baroreflex - drug effects Baroreflex - physiology Blood pressure Central nervous system Infusions, Intraventricular Losartan Male Microglia Microglia - drug effects Microglia - physiology Minocycline Minocycline - pharmacology Proinflammatory cytokines Rats Rats, Sprague-Dawley Receptor, Angiotensin, Type 1 - physiology Saline Solution, Hypertonic - administration & dosage Saline Solution, Hypertonic - pharmacology Sodium
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