$Blockade of the fractalkine-CX3CR1 axis ameliorates experimental colitis by dislodging venous crawling monocytes$

Blockade of the fractalkine-CX3CR1 axis ameliorates experimental colitis by dislodging venous crawling monocytes

Chemokine systems modulate inflammatory and immune responses in inflammatory bowel disease (IBD). The colons of IBD patients show increased levels of fractalkine (FKN) and high numbers of FKN receptor-positive (CX3CR1+) cells; however, the FKN-CX3CR1 axis's role in intestinal inflammation, espe...

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Veröffentlicht in:	International immunology 2019-04, Vol.31 (5), p.287-302
Hauptverfasser:	Kuboi, Yoshikazu, Nishimura, Miyuki, Ikeda, Wataru, Nakatani, Tomoya, Seki, Yukie, Yamaura, Yui, Ogawa, Kana, Hamaguchi, Akiko, Muramoto, Kenzo, Mizuno, Keiko, Ogasawara, Hideaki, Yamauchi, Toshihiko, Yasuda, Nobuyuki, Onodera, Hiroshi, Imai, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Rectal Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Chemokine CX3CL1 - antagonists & inhibitors Chemokine CX3CL1 - immunology Colitis - chemically induced Colitis - drug therapy Colitis - immunology CX3C Chemokine Receptor 1 - antagonists & inhibitors CX3C Chemokine Receptor 1 - immunology Female Humans Male Mice Mice, Inbred BALB C Monocytes - drug effects Monocytes - immunology Oxazoles
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