Does Primary Hyperparathyroidism Have an Association with Thyroid Papillary Cancer? A Retrospective Cohort Study

Background To investigate the relationship between primary hyperparathyroidism (pHPT) and papillary thyroid cancer (PTC). Methods The perioperative findings of 275 patients with pHPT who underwent surgery between January 2014 and December 2017 were retrospectively reviewed. Thirty-one patients were...

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Veröffentlicht in:World journal of surgery 2019-05, Vol.43 (5), p.1243-1248
Hauptverfasser: Çetin, Kenan, Sıkar, Hasan E., Temizkan, Şule, Ofluoğlu, Cem B., Özderya, Ayşenur, Aydın, Kadriye, Gül, Aylin E., Küçük, Hasan F.
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container_end_page 1248
container_issue 5
container_start_page 1243
container_title World journal of surgery
container_volume 43
creator Çetin, Kenan
Sıkar, Hasan E.
Temizkan, Şule
Ofluoğlu, Cem B.
Özderya, Ayşenur
Aydın, Kadriye
Gül, Aylin E.
Küçük, Hasan F.
description Background To investigate the relationship between primary hyperparathyroidism (pHPT) and papillary thyroid cancer (PTC). Methods The perioperative findings of 275 patients with pHPT who underwent surgery between January 2014 and December 2017 were retrospectively reviewed. Thirty-one patients were diagnosed with pHPT and PTC concurrently. Pathology results and demographic findings of these patients were compared with 186 patients who underwent thyroidectomy and diagnosed with PTC at the same time interval. Results The co-occurrence of pHPT and PTC was 11.3% (31/275). The median ages of the pHPT, pHPT + PTC, and PTC groups were 55, 57, and 50 years old, respectively ( p 
doi_str_mv 10.1007/s00268-019-04920-4
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A Retrospective Cohort Study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SpringerLink Journals</source><creator>Çetin, Kenan ; Sıkar, Hasan E. ; Temizkan, Şule ; Ofluoğlu, Cem B. ; Özderya, Ayşenur ; Aydın, Kadriye ; Gül, Aylin E. ; Küçük, Hasan F.</creator><creatorcontrib>Çetin, Kenan ; Sıkar, Hasan E. ; Temizkan, Şule ; Ofluoğlu, Cem B. ; Özderya, Ayşenur ; Aydın, Kadriye ; Gül, Aylin E. ; Küçük, Hasan F.</creatorcontrib><description>Background To investigate the relationship between primary hyperparathyroidism (pHPT) and papillary thyroid cancer (PTC). Methods The perioperative findings of 275 patients with pHPT who underwent surgery between January 2014 and December 2017 were retrospectively reviewed. Thirty-one patients were diagnosed with pHPT and PTC concurrently. Pathology results and demographic findings of these patients were compared with 186 patients who underwent thyroidectomy and diagnosed with PTC at the same time interval. Results The co-occurrence of pHPT and PTC was 11.3% (31/275). The median ages of the pHPT, pHPT + PTC, and PTC groups were 55, 57, and 50 years old, respectively ( p  &lt; 0.001). The diameter of tumor was smaller in the pHPT + PTC group [median 7 mm (range 0.5–25 mm) vs. 15 mm (range 1–100 mm)], with higher rates of microcarcinomas ( p  &lt; 0.001), than the patients in the PTC group. Examination of tumor morphology showed higher rates of tumor capsule invasion and multicentricity in the pHPT + PTC group than those in the isolated PTC group ( p  = 0.02, p  = 0.04, respectively). Conclusion The pHPT + PTC group had significantly smaller tumor diameter than the PTC group. This result may support the idea that pHPT leads to overdiagnosis of PTC. However, observation of high rates of tumor capsule invasion and multicentricity in the pHPT + PTC group may suggest an associative etiology with more aggressive PTC.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-019-04920-4</identifier><identifier>PMID: 30680499</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abdominal Surgery ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cancer ; Cardiac Surgery ; Cohort analysis ; Demographics ; Etiology ; Female ; General Surgery ; Humans ; Hyperparathyroidism ; Hyperparathyroidism, Primary - complications ; Hyperparathyroidism, Primary - surgery ; Male ; Medical Overuse ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Morphology ; Original Scientific Report ; Papillary thyroid cancer ; Patients ; Retrospective Studies ; Surgery ; Thoracic Surgery ; Thyroid ; Thyroid cancer ; Thyroid Cancer, Papillary - diagnostic imaging ; Thyroid Cancer, Papillary - etiology ; Thyroid Cancer, Papillary - pathology ; Thyroid Cancer, Papillary - surgery ; Thyroid gland ; Thyroid Neoplasms - diagnostic imaging ; Thyroid Neoplasms - etiology ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Thyroidectomy - methods ; Tumors ; Vascular Surgery ; Young Adult</subject><ispartof>World journal of surgery, 2019-05, Vol.43 (5), p.1243-1248</ispartof><rights>Société Internationale de Chirurgie 2019</rights><rights>2019 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><rights>World Journal of Surgery is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4263-acb3c369a2436daf77d1ed7707524775a045cbb6f550aab62e0919cbb91964a33</citedby><cites>FETCH-LOGICAL-c4263-acb3c369a2436daf77d1ed7707524775a045cbb6f550aab62e0919cbb91964a33</cites><orcidid>0000-0003-0640-7218 ; 0000-0003-0441-4617 ; 0000-0003-0928-6191 ; 0000-0002-0450-755X ; 0000-0002-8616-9784 ; 0000-0003-3989-303X ; 0000-0002-0670-8590 ; 0000-0002-5725-0903</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-019-04920-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-019-04920-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,41464,42533,45550,45551,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30680499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Çetin, Kenan</creatorcontrib><creatorcontrib>Sıkar, Hasan E.</creatorcontrib><creatorcontrib>Temizkan, Şule</creatorcontrib><creatorcontrib>Ofluoğlu, Cem B.</creatorcontrib><creatorcontrib>Özderya, Ayşenur</creatorcontrib><creatorcontrib>Aydın, Kadriye</creatorcontrib><creatorcontrib>Gül, Aylin E.</creatorcontrib><creatorcontrib>Küçük, Hasan F.</creatorcontrib><title>Does Primary Hyperparathyroidism Have an Association with Thyroid Papillary Cancer? A Retrospective Cohort Study</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Background To investigate the relationship between primary hyperparathyroidism (pHPT) and papillary thyroid cancer (PTC). Methods The perioperative findings of 275 patients with pHPT who underwent surgery between January 2014 and December 2017 were retrospectively reviewed. Thirty-one patients were diagnosed with pHPT and PTC concurrently. Pathology results and demographic findings of these patients were compared with 186 patients who underwent thyroidectomy and diagnosed with PTC at the same time interval. Results The co-occurrence of pHPT and PTC was 11.3% (31/275). The median ages of the pHPT, pHPT + PTC, and PTC groups were 55, 57, and 50 years old, respectively ( p  &lt; 0.001). The diameter of tumor was smaller in the pHPT + PTC group [median 7 mm (range 0.5–25 mm) vs. 15 mm (range 1–100 mm)], with higher rates of microcarcinomas ( p  &lt; 0.001), than the patients in the PTC group. Examination of tumor morphology showed higher rates of tumor capsule invasion and multicentricity in the pHPT + PTC group than those in the isolated PTC group ( p  = 0.02, p  = 0.04, respectively). Conclusion The pHPT + PTC group had significantly smaller tumor diameter than the PTC group. This result may support the idea that pHPT leads to overdiagnosis of PTC. However, observation of high rates of tumor capsule invasion and multicentricity in the pHPT + PTC group may suggest an associative etiology with more aggressive PTC.</description><subject>Abdominal Surgery</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer</subject><subject>Cardiac Surgery</subject><subject>Cohort analysis</subject><subject>Demographics</subject><subject>Etiology</subject><subject>Female</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Hyperparathyroidism</subject><subject>Hyperparathyroidism, Primary - complications</subject><subject>Hyperparathyroidism, Primary - surgery</subject><subject>Male</subject><subject>Medical Overuse</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Original Scientific Report</subject><subject>Papillary thyroid cancer</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Thoracic Surgery</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroid Cancer, Papillary - diagnostic imaging</subject><subject>Thyroid Cancer, Papillary - etiology</subject><subject>Thyroid Cancer, Papillary - pathology</subject><subject>Thyroid Cancer, Papillary - surgery</subject><subject>Thyroid gland</subject><subject>Thyroid Neoplasms - diagnostic imaging</subject><subject>Thyroid Neoplasms - etiology</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><subject>Thyroidectomy - methods</subject><subject>Tumors</subject><subject>Vascular Surgery</subject><subject>Young Adult</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU9v0zAYhy0E2srYF-CALHHhku31n9g1F9QVtoImraJDO1qO41JPbZzZCVO-Pe6ygcQB7WJb1vO8-tk_hN4SOCEA8jQBUDEtgKgCuKJQ8BdoQjijBWWUvUQTYILnM2GH6HVKtwBEChAH6JCBmGZFTVD7ObiEl9HvTBzwYmhdbE003WaIwdc-7fDC_HLYNHiWUrDedD40-N53G3w9MnhpWr_d7vW5aayLn_AMf3ddDKl1tvPZnodNiB1edX09vEGv1mab3PHjfoR-nH-5ni-Ky6uLr_PZZWE5FawwtmKWCWUoZ6I2aylr4mopQZaUS1ka4KWtKrEuSzCmEtSBIirf5FVww9gR-jDObWO4613q9M4n63LQxoU-aUqk4lxwRTL6_h_0NvSxyen2FEhFp1OVKTpSNr8sRbfW7fhrmoDe96HHPnTuQz_0oXmW3j2O7qudq_8oTwVk4OMI3PutG54xUt98W52dg6Jq_0Y2yil7zU8X_wb_T6bfBH6nEg</recordid><startdate>20190515</startdate><enddate>20190515</enddate><creator>Çetin, Kenan</creator><creator>Sıkar, Hasan E.</creator><creator>Temizkan, Şule</creator><creator>Ofluoğlu, Cem B.</creator><creator>Özderya, Ayşenur</creator><creator>Aydın, Kadriye</creator><creator>Gül, Aylin E.</creator><creator>Küçük, Hasan F.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0640-7218</orcidid><orcidid>https://orcid.org/0000-0003-0441-4617</orcidid><orcidid>https://orcid.org/0000-0003-0928-6191</orcidid><orcidid>https://orcid.org/0000-0002-0450-755X</orcidid><orcidid>https://orcid.org/0000-0002-8616-9784</orcidid><orcidid>https://orcid.org/0000-0003-3989-303X</orcidid><orcidid>https://orcid.org/0000-0002-0670-8590</orcidid><orcidid>https://orcid.org/0000-0002-5725-0903</orcidid></search><sort><creationdate>20190515</creationdate><title>Does Primary Hyperparathyroidism Have an Association with Thyroid Papillary Cancer? A Retrospective Cohort Study</title><author>Çetin, Kenan ; Sıkar, Hasan E. ; Temizkan, Şule ; Ofluoğlu, Cem B. ; Özderya, Ayşenur ; Aydın, Kadriye ; Gül, Aylin E. ; Küçük, Hasan F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4263-acb3c369a2436daf77d1ed7707524775a045cbb6f550aab62e0919cbb91964a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdominal Surgery</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Cardiac Surgery</topic><topic>Cohort analysis</topic><topic>Demographics</topic><topic>Etiology</topic><topic>Female</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Hyperparathyroidism</topic><topic>Hyperparathyroidism, Primary - complications</topic><topic>Hyperparathyroidism, Primary - surgery</topic><topic>Male</topic><topic>Medical Overuse</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Original Scientific Report</topic><topic>Papillary thyroid cancer</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Thoracic Surgery</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Thyroid Cancer, Papillary - diagnostic imaging</topic><topic>Thyroid Cancer, Papillary - etiology</topic><topic>Thyroid Cancer, Papillary - pathology</topic><topic>Thyroid Cancer, Papillary - surgery</topic><topic>Thyroid gland</topic><topic>Thyroid Neoplasms - diagnostic imaging</topic><topic>Thyroid Neoplasms - etiology</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Thyroidectomy - methods</topic><topic>Tumors</topic><topic>Vascular Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Çetin, Kenan</creatorcontrib><creatorcontrib>Sıkar, Hasan E.</creatorcontrib><creatorcontrib>Temizkan, Şule</creatorcontrib><creatorcontrib>Ofluoğlu, Cem B.</creatorcontrib><creatorcontrib>Özderya, Ayşenur</creatorcontrib><creatorcontrib>Aydın, Kadriye</creatorcontrib><creatorcontrib>Gül, Aylin E.</creatorcontrib><creatorcontrib>Küçük, Hasan F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Çetin, Kenan</au><au>Sıkar, Hasan E.</au><au>Temizkan, Şule</au><au>Ofluoğlu, Cem B.</au><au>Özderya, Ayşenur</au><au>Aydın, Kadriye</au><au>Gül, Aylin E.</au><au>Küçük, Hasan F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does Primary Hyperparathyroidism Have an Association with Thyroid Papillary Cancer? A Retrospective Cohort Study</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2019-05-15</date><risdate>2019</risdate><volume>43</volume><issue>5</issue><spage>1243</spage><epage>1248</epage><pages>1243-1248</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract>Background To investigate the relationship between primary hyperparathyroidism (pHPT) and papillary thyroid cancer (PTC). Methods The perioperative findings of 275 patients with pHPT who underwent surgery between January 2014 and December 2017 were retrospectively reviewed. Thirty-one patients were diagnosed with pHPT and PTC concurrently. Pathology results and demographic findings of these patients were compared with 186 patients who underwent thyroidectomy and diagnosed with PTC at the same time interval. Results The co-occurrence of pHPT and PTC was 11.3% (31/275). The median ages of the pHPT, pHPT + PTC, and PTC groups were 55, 57, and 50 years old, respectively ( p  &lt; 0.001). The diameter of tumor was smaller in the pHPT + PTC group [median 7 mm (range 0.5–25 mm) vs. 15 mm (range 1–100 mm)], with higher rates of microcarcinomas ( p  &lt; 0.001), than the patients in the PTC group. Examination of tumor morphology showed higher rates of tumor capsule invasion and multicentricity in the pHPT + PTC group than those in the isolated PTC group ( p  = 0.02, p  = 0.04, respectively). Conclusion The pHPT + PTC group had significantly smaller tumor diameter than the PTC group. This result may support the idea that pHPT leads to overdiagnosis of PTC. However, observation of high rates of tumor capsule invasion and multicentricity in the pHPT + PTC group may suggest an associative etiology with more aggressive PTC.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30680499</pmid><doi>10.1007/s00268-019-04920-4</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0640-7218</orcidid><orcidid>https://orcid.org/0000-0003-0441-4617</orcidid><orcidid>https://orcid.org/0000-0003-0928-6191</orcidid><orcidid>https://orcid.org/0000-0002-0450-755X</orcidid><orcidid>https://orcid.org/0000-0002-8616-9784</orcidid><orcidid>https://orcid.org/0000-0003-3989-303X</orcidid><orcidid>https://orcid.org/0000-0002-0670-8590</orcidid><orcidid>https://orcid.org/0000-0002-5725-0903</orcidid></addata></record>
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source MEDLINE; Wiley Online Library Journals Frontfile Complete; SpringerLink Journals
subjects Abdominal Surgery
Adolescent
Adult
Aged
Aged, 80 and over
Cancer
Cardiac Surgery
Cohort analysis
Demographics
Etiology
Female
General Surgery
Humans
Hyperparathyroidism
Hyperparathyroidism, Primary - complications
Hyperparathyroidism, Primary - surgery
Male
Medical Overuse
Medicine
Medicine & Public Health
Middle Aged
Morphology
Original Scientific Report
Papillary thyroid cancer
Patients
Retrospective Studies
Surgery
Thoracic Surgery
Thyroid
Thyroid cancer
Thyroid Cancer, Papillary - diagnostic imaging
Thyroid Cancer, Papillary - etiology
Thyroid Cancer, Papillary - pathology
Thyroid Cancer, Papillary - surgery
Thyroid gland
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - etiology
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy
Thyroidectomy - methods
Tumors
Vascular Surgery
Young Adult
title Does Primary Hyperparathyroidism Have an Association with Thyroid Papillary Cancer? A Retrospective Cohort Study
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