Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp

The total synthesis of majusculamide D (MJS-D) is described, a lipopentapeptide originally isolated from Lyngbya majuscula and reisolated from a Moorea sp. MJS-D possesses selective and potent cancer cell toxicity. A scalable and convergent strategy with a minimal number of purifications produced si...

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Veröffentlicht in:	Organic letters 2019-02, Vol.21 (3), p.793-796
Hauptverfasser:	Caro-Diaz, Eduardo J. E, Valeriote, Frederick A, Gerwick, William H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Chemistry Techniques, Synthetic Cyanobacteria - chemistry Humans Lipopeptides - chemical synthesis Lipopeptides - chemistry Lipopeptides - pharmacology Stereoisomerism
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