Bone regeneration using three‐dimensional hexahedron channel structured BCP block in rabbit calvarial defects
The purpose of this study is to evaluate the efficacy of bone regeneration and volume maintenance of the three‐dimensional (3D) structured biphasic calcium phosphate (BCP) block with porous hexahedron channels in a rabbit calvarial model. In this work, four circular defects (diameter: 8 mm) in calva...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2019-10, Vol.107 (7), p.2254-2262 |
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| container_title | Journal of biomedical materials research. Part B, Applied biomaterials |
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| creator | Pae, Hyung‐Chul Kang, Joo‐Hyun Cha, Jae‐Kook Lee, Jung‐Seok Paik, Jeong‐Won Jung, Ui‐Won Choi, Seong‐Ho |
| description | The purpose of this study is to evaluate the efficacy of bone regeneration and volume maintenance of the three‐dimensional (3D) structured biphasic calcium phosphate (BCP) block with porous hexahedron channels in a rabbit calvarial model. In this work, four circular defects (diameter: 8 mm) in calvarium of rabbits were randomly assigned to (1) negative control (control), (2) 3D hexahedron channel structured BCP block, (3) deproteinized bovine bone mineral particle, and (4) deproteinized porcine bone mineral particle. Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Outcome measures included micro‐computed tomography (CT) and histomorphometrical analysis. Results indicated that in micro‐CT, BCP group showed the highest new bone volume with significant difference compared to control (p = 0.008) at 8 weeks. Histomorphometrically, total augmented area of BCP group was the highest with significant difference compared to control (p = 0.008) at 8 weeks. BCP group also maintained total volume of the original defect without collapsing. BCP block with 3D hexahedron channel structure seems to have favorable osteogenic and volume maintaining ability and highly porous structure might attribute to new bone formation. Further studies regarding the optimal internal structure and porosity of the BCP block bone substitute are needed. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2254–2262, 2019. |
| doi_str_mv | 10.1002/jbm.b.34317 |
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In this work, four circular defects (diameter: 8 mm) in calvarium of rabbits were randomly assigned to (1) negative control (control), (2) 3D hexahedron channel structured BCP block, (3) deproteinized bovine bone mineral particle, and (4) deproteinized porcine bone mineral particle. Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Outcome measures included micro‐computed tomography (CT) and histomorphometrical analysis. Results indicated that in micro‐CT, BCP group showed the highest new bone volume with significant difference compared to control (p = 0.008) at 8 weeks. Histomorphometrically, total augmented area of BCP group was the highest with significant difference compared to control (p = 0.008) at 8 weeks. BCP group also maintained total volume of the original defect without collapsing. BCP block with 3D hexahedron channel structure seems to have favorable osteogenic and volume maintaining ability and highly porous structure might attribute to new bone formation. Further studies regarding the optimal internal structure and porosity of the BCP block bone substitute are needed. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2254–2262, 2019.</description><identifier>ISSN: 1552-4973</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.34317</identifier><identifier>PMID: 30675991</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>3D structure ; Biomedical materials ; biphasic calcium phosphate ; Bone growth ; bone regeneration ; Calcium ; Calcium phosphates ; Computed tomography ; Defects ; Materials research ; Materials science ; Osteogenesis ; Porosity ; Rabbits ; Regeneration ; Regeneration (physiology) ; Substitute bone ; Surgical implants ; synthetic</subject><ispartof>Journal of biomedical materials research. Part B, Applied biomaterials, 2019-10, Vol.107 (7), p.2254-2262</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3977-c106ba7cca5517a9bea01a9eed84a03cbeaeaea33417db2b1bb3dd44f2d08b133</citedby><cites>FETCH-LOGICAL-c3977-c106ba7cca5517a9bea01a9eed84a03cbeaeaea33417db2b1bb3dd44f2d08b133</cites><orcidid>0000-0002-6365-3557</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.b.34317$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.b.34317$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30675991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pae, Hyung‐Chul</creatorcontrib><creatorcontrib>Kang, Joo‐Hyun</creatorcontrib><creatorcontrib>Cha, Jae‐Kook</creatorcontrib><creatorcontrib>Lee, Jung‐Seok</creatorcontrib><creatorcontrib>Paik, Jeong‐Won</creatorcontrib><creatorcontrib>Jung, Ui‐Won</creatorcontrib><creatorcontrib>Choi, Seong‐Ho</creatorcontrib><title>Bone regeneration using three‐dimensional hexahedron channel structured BCP block in rabbit calvarial defects</title><title>Journal of biomedical materials research. Part B, Applied biomaterials</title><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><description>The purpose of this study is to evaluate the efficacy of bone regeneration and volume maintenance of the three‐dimensional (3D) structured biphasic calcium phosphate (BCP) block with porous hexahedron channels in a rabbit calvarial model. In this work, four circular defects (diameter: 8 mm) in calvarium of rabbits were randomly assigned to (1) negative control (control), (2) 3D hexahedron channel structured BCP block, (3) deproteinized bovine bone mineral particle, and (4) deproteinized porcine bone mineral particle. Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Outcome measures included micro‐computed tomography (CT) and histomorphometrical analysis. Results indicated that in micro‐CT, BCP group showed the highest new bone volume with significant difference compared to control (p = 0.008) at 8 weeks. Histomorphometrically, total augmented area of BCP group was the highest with significant difference compared to control (p = 0.008) at 8 weeks. BCP group also maintained total volume of the original defect without collapsing. BCP block with 3D hexahedron channel structure seems to have favorable osteogenic and volume maintaining ability and highly porous structure might attribute to new bone formation. Further studies regarding the optimal internal structure and porosity of the BCP block bone substitute are needed. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2254–2262, 2019.</description><subject>3D structure</subject><subject>Biomedical materials</subject><subject>biphasic calcium phosphate</subject><subject>Bone growth</subject><subject>bone regeneration</subject><subject>Calcium</subject><subject>Calcium phosphates</subject><subject>Computed tomography</subject><subject>Defects</subject><subject>Materials research</subject><subject>Materials science</subject><subject>Osteogenesis</subject><subject>Porosity</subject><subject>Rabbits</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Substitute bone</subject><subject>Surgical implants</subject><subject>synthetic</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp90blOAzEQBmALgQgEKnpkiQYJJdhrb5wtScQpEBRQWz4micOuF-xdjo5H4Bl5EhwCFBTIhQ99_qWZQWiHkj4lJDuc66qv-4wzKlbQBs3zrMeLIV39PQvWQZsxzhMekJytow4jA5EXBd1A9aj2gANMwUNQjas9bqPzU9zMAsDH27t1FfiY3lWJZ_CiZmBDQmamvIcSxya0pmkDWDwa32Bd1uYeO4-D0to12KjySQWX_lqYgGniFlqbqDLC9vfeRXcnx7fjs97l9en5-OiyZ1ghRM9QMtBKGKPynApVaFCEqgLADrkizKT7YjHGqbA601RrZi3nk8ySoaaMddH-Mvch1I8txEZWLhooS-WhbqPMqCg4Z6kdie79ofO6DanepLIhyzhdsC46WCoT6hgDTORDcJUKr5ISuZiDTHOQWn7NIend78xWV2B_7U_jE8iW4NmV8PpflrwYXY2WqZ81EpZJ</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Pae, Hyung‐Chul</creator><creator>Kang, Joo‐Hyun</creator><creator>Cha, Jae‐Kook</creator><creator>Lee, Jung‐Seok</creator><creator>Paik, Jeong‐Won</creator><creator>Jung, Ui‐Won</creator><creator>Choi, Seong‐Ho</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6365-3557</orcidid></search><sort><creationdate>201910</creationdate><title>Bone regeneration using three‐dimensional hexahedron channel structured BCP block in rabbit calvarial defects</title><author>Pae, Hyung‐Chul ; Kang, Joo‐Hyun ; Cha, Jae‐Kook ; Lee, Jung‐Seok ; Paik, Jeong‐Won ; Jung, Ui‐Won ; Choi, Seong‐Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3977-c106ba7cca5517a9bea01a9eed84a03cbeaeaea33417db2b1bb3dd44f2d08b133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>3D structure</topic><topic>Biomedical materials</topic><topic>biphasic calcium phosphate</topic><topic>Bone growth</topic><topic>bone regeneration</topic><topic>Calcium</topic><topic>Calcium phosphates</topic><topic>Computed tomography</topic><topic>Defects</topic><topic>Materials research</topic><topic>Materials science</topic><topic>Osteogenesis</topic><topic>Porosity</topic><topic>Rabbits</topic><topic>Regeneration</topic><topic>Regeneration (physiology)</topic><topic>Substitute bone</topic><topic>Surgical implants</topic><topic>synthetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pae, Hyung‐Chul</creatorcontrib><creatorcontrib>Kang, Joo‐Hyun</creatorcontrib><creatorcontrib>Cha, Jae‐Kook</creatorcontrib><creatorcontrib>Lee, Jung‐Seok</creatorcontrib><creatorcontrib>Paik, Jeong‐Won</creatorcontrib><creatorcontrib>Jung, Ui‐Won</creatorcontrib><creatorcontrib>Choi, Seong‐Ho</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pae, Hyung‐Chul</au><au>Kang, Joo‐Hyun</au><au>Cha, Jae‐Kook</au><au>Lee, Jung‐Seok</au><au>Paik, Jeong‐Won</au><au>Jung, Ui‐Won</au><au>Choi, Seong‐Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone regeneration using three‐dimensional hexahedron channel structured BCP block in rabbit calvarial defects</atitle><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><date>2019-10</date><risdate>2019</risdate><volume>107</volume><issue>7</issue><spage>2254</spage><epage>2262</epage><pages>2254-2262</pages><issn>1552-4973</issn><eissn>1552-4981</eissn><abstract>The purpose of this study is to evaluate the efficacy of bone regeneration and volume maintenance of the three‐dimensional (3D) structured biphasic calcium phosphate (BCP) block with porous hexahedron channels in a rabbit calvarial model. In this work, four circular defects (diameter: 8 mm) in calvarium of rabbits were randomly assigned to (1) negative control (control), (2) 3D hexahedron channel structured BCP block, (3) deproteinized bovine bone mineral particle, and (4) deproteinized porcine bone mineral particle. Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Outcome measures included micro‐computed tomography (CT) and histomorphometrical analysis. Results indicated that in micro‐CT, BCP group showed the highest new bone volume with significant difference compared to control (p = 0.008) at 8 weeks. Histomorphometrically, total augmented area of BCP group was the highest with significant difference compared to control (p = 0.008) at 8 weeks. BCP group also maintained total volume of the original defect without collapsing. BCP block with 3D hexahedron channel structure seems to have favorable osteogenic and volume maintaining ability and highly porous structure might attribute to new bone formation. Further studies regarding the optimal internal structure and porosity of the BCP block bone substitute are needed. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2254–2262, 2019.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30675991</pmid><doi>10.1002/jbm.b.34317</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6365-3557</orcidid></addata></record> |
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| subjects | 3D structure Biomedical materials biphasic calcium phosphate Bone growth bone regeneration Calcium Calcium phosphates Computed tomography Defects Materials research Materials science Osteogenesis Porosity Rabbits Regeneration Regeneration (physiology) Substitute bone Surgical implants synthetic |
| title | Bone regeneration using three‐dimensional hexahedron channel structured BCP block in rabbit calvarial defects |
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