Brefeldin A inhibits colorectal cancer growth by triggering Bip/Akt‐regulated autophagy

ABSTRACTColorectal cancer (CRC) is one of the most prevalent neoplastic diseases worldwide, and effective treatment remains a challenge. Here, we found that the macrolide antibiotic brefeldin A (BFA) exhibits considerable antitumor activity both in vitro and in vivo. Induction of complete autophagic...

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Veröffentlicht in:	The FASEB journal 2019-04, Vol.33 (4), p.5520-5534
Hauptverfasser:	Zhou, Li, Gao, Wei, Wang, Kui, Huang, Zhao, Zhang, Lu, Zhang, Zhe, Zhou, Jing, Nice, Edouard C., Huang, Canhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology autophagic flux Autophagy - drug effects Brefeldin A - pharmacology cancer therapy Cell Line, Tumor Cell Proliferation - drug effects Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Endoplasmic Reticulum Stress - drug effects ER stress HCT116 Cells HT29 Cells Humans Lymphokines - metabolism Macrolides - metabolism Mice Mice, Inbred BALB C Mice, Nude Proto-Oncogene Proteins c-akt - metabolism
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