Association of nuclear localization of SHP2 and YAP1 with unfavorable prognosis in non-small cell lung cancer

Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) is ubiquitously expressed in cytoplasmic localization, which in turn confers tumor malignancy and poor prognosis in various human cancers. YAP1 interacts with SHP2 to promote translocation of SHP2 to nucleus, which conseque...

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Veröffentlicht in:	Pathology, research and practice research and practice, 2019-04, Vol.215 (4), p.801-806
Hauptverfasser:	Chen, Ming-Jenn, Wang, Yao-Chen, Wu, De-Wei, Chen, Chi-Yi, Lee, Huei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Aged beta Catenin - metabolism Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Cell Nucleus - metabolism Cyclin D1 - metabolism Female Humans Immunohistochemistry Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Male Middle Aged NSCLC Phosphoproteins - metabolism Prognosis Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism Proto-Oncogene Proteins c-myc - metabolism SHP2 Signal Transduction - physiology Survival Rate Transcription Factors
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