Crown Ethers as Transthyretin Amyloidogenesis Inhibitors

Transthyretin (TTR) is a tetrameric protein found in human serum and associated with amyloid diseases. Because the tetramer dissociation and misfolding of the monomer precede amyloid fibril formation, development of a small molecule that binds to TTR and stabilizes the TTR tetramer is an efficient s...

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Veröffentlicht in:	Journal of medicinal chemistry 2019-02, Vol.62 (4), p.2076-2082
Hauptverfasser:	Yokoyama, Takeshi, Mizuguchi, Mineyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Site Amyloidogenic Proteins - chemistry Amyloidogenic Proteins - metabolism Crown Ethers - metabolism Crystallography, X-Ray Diflunisal - metabolism Drug Discovery Humans Prealbumin - chemistry Prealbumin - metabolism Protein Binding Protein Multimerization - drug effects
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