Investigating the Value of Urine Volume, Creatinine, and Cystatin C for Urinary Biomarkers Normalization for Drug Development Studies

Novel urinary protein biomarkers have recently been identified and qualified in rats for the early detection of renal injury in drug development studies. However, there seems to be no standardized normalization method for analyzing these urinary biomarkers, as some users normalize with urinary creat...

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Veröffentlicht in:	International journal of toxicology 2019-01, Vol.38 (1), p.12-22
Hauptverfasser:	Adedeji, Adeyemi O., Pourmohamad, Tony, Chen, Yafei, Burkey, Jennifer, Betts, Catherine J., Bickerton, Susan J., Sonee, Manisha, McDuffie, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - pathology Acute Kidney Injury - urine Animals Animals, Outbred Strains Biomarkers - urine Creatinine - urine Cystatin C - urine Drug Development Female Kidney - pathology Male Rats, Sprague-Dawley Urinalysis
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