Total Synthesis of the Trisaccharide Antigen of the Campylobacter jejuni RM1221 Capsular Polysaccharide via de Novo Synthesis of the 6‑Deoxy‑d-manno-heptose Building Blocks

A de novo approach utilizing the d-proline-catalyzed and LDA-promoted aldol reactions as key steps for the preparation of differentiated-protected 6-deoxy-d-manno-heptose building blocks was developed. PPh3AuBAr4 F-catalyzed glycosylation with the 6-deoxy-d-manno-heptosyl o-hexynylbenzoate as donor...

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Veröffentlicht in:	Journal of organic chemistry 2019-03, Vol.84 (5), p.2393-2403
Hauptverfasser:	Wang, Xiaoman, Chen, Yan, Wang, Junchang, Yang, You
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Bacterial - chemistry Antigens, Bacterial - immunology Bacterial Capsules - chemistry Bacterial Capsules - immunology Campylobacter jejuni - immunology Glycosylation Heptoses - chemical synthesis Polysaccharides, Bacterial - chemistry Polysaccharides, Bacterial - immunology Trisaccharides - chemical synthesis Trisaccharides - immunology
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