A Candidate-Gene Approach Identifies Novel Associations Between Common Variants in/Near Syndromic Obesity Genes and BMI in Pediatric and Adult European Populations

We hypothesized that monogenic syndromic obesity genes are also involved in the polygenic variation of BMI. Single-marker, tag single nucleotide polymorphism (tagSNP) and gene-based analysis were performed on common variants near 54 syndromic obesity genes. We used publicly available data from meta-...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2019-04, Vol.68 (4), p.724-732
Hauptverfasser:	Wang, Dominic X, Kaur, Yuvreet, Alyass, Akram, Meyre, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Body mass index Gene polymorphism Genes Genome-wide association studies Genomes Obesity Pediatrics Polygenic inheritance Single-nucleotide polymorphism
Online-Zugang:	Volltext
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