Metastatic Tumor-in-a-Dish, a Novel Multicellular Organoid to Study Lung Colonization and Predict Therapeutic Response

Metastasis is a major cause of cancer-related deaths. A dearth of preclinical models that recapitulate the metastatic microenvironment has impeded the development of therapeutic agents that are effective against metastatic disease. Because the majority of solid tumors metastasize to the lung, we dev...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2019-04, Vol.79 (7), p.1681-1695
Hauptverfasser:	Ramamoorthy, Prabhu, Thomas, Sufi Mary, Kaushik, Gaurav, Subramaniam, Dharmalingam, Chastain, Katherine M, Dhar, Animesh, Tawfik, Ossama, Kasi, Anup, Sun, Weijing, Ramalingam, Satish, Gunewardena, Sumedha, Umar, Shahid, Mammen, Joshua M, Padhye, Subhash B, Weir, Scott J, Jensen, Roy A, Sittampalam, G Sitta, Anant, Shrikant
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Cell Line Cell Line, Tumor Drug Screening Assays, Antitumor Female Humans Lung Neoplasms - drug therapy Lung Neoplasms - secondary Neoplasm Metastasis Organoids - pathology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Tumor Microenvironment
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