Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective
Crocin is the major component of saffron, which is used in phytomedicine for the treatment of several diseases including diabetes, fatty liver, depression, menstruation disorders, and, of special interest in this review, inflammatory diseases. Promising selective anti‐inflammatory properties of this...
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| Veröffentlicht in: | Journal of cellular physiology 2019-09, Vol.234 (9), p.14601-14611 |
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| creator | Pashirzad, Mehran Shafiee, Mojtaba Avan, Amir Ryzhikov, Mikhail Fiuji, Hamid Bahreyni, Amirhossein Khazaei, Majid Soleimanpour, Saman Hassanian, Seyed Mahdi |
| description | Crocin is the major component of saffron, which is used in phytomedicine for the treatment of several diseases including diabetes, fatty liver, depression, menstruation disorders, and, of special interest in this review, inflammatory diseases. Promising selective anti‐inflammatory properties of this pharmacological active component have been observed in several studies. Saffron has been shown to exert anti‐inflammatory properties against several inflammatory diseases and can be used as a novel therapeutic agent for the treatment of inflammatory diseases either alone or in combination with other standard anti‐inflammatory agents. This review summarizes the protective role of saffron and its pharmacologically active constituents in the pathogenesis of inflammatory diseases including digestive diseases, dermatitis, asthma, atherosclerosis, and neurodegenerative diseases for a better understanding and hence a better management of these diseases.
Saffron has been shown to exert anti‐inflammatory properties against several inflammatory diseases and can be used as a novel therapeutic agent for the treatment of inflammatory diseases either alone or in combination with other standard anti‐inflammatory agents. This review summarizes the protective role of saffron and its pharmacologically active constituents in the pathogenesis of inflammatory diseases including digestive diseases, dermatitis, asthma, atherosclerosis, and neurodegenerative diseases for a better understanding and hence a better management of these diseases. |
| doi_str_mv | 10.1002/jcp.28177 |
| format | Article |
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Saffron has been shown to exert anti‐inflammatory properties against several inflammatory diseases and can be used as a novel therapeutic agent for the treatment of inflammatory diseases either alone or in combination with other standard anti‐inflammatory agents. This review summarizes the protective role of saffron and its pharmacologically active constituents in the pathogenesis of inflammatory diseases including digestive diseases, dermatitis, asthma, atherosclerosis, and neurodegenerative diseases for a better understanding and hence a better management of these diseases.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.28177</identifier><identifier>PMID: 30673132</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Arteriosclerosis ; Asthma ; Atherosclerosis ; Chemical compounds ; crocin ; Dermatitis ; Diabetes mellitus ; Digestive system diseases ; Fatty liver ; Inflammatory diseases ; Liver diseases ; Menstruation ; Neurodegenerative diseases ; Neurological diseases ; Pathogenesis ; Pharmacology ; Saffron</subject><ispartof>Journal of cellular physiology, 2019-09, Vol.234 (9), p.14601-14611</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4197-5a614d4336317e3f6963c6aeed47e98d51c6f029c0c2288360ca7eb54a3a58873</citedby><cites>FETCH-LOGICAL-c4197-5a614d4336317e3f6963c6aeed47e98d51c6f029c0c2288360ca7eb54a3a58873</cites><orcidid>0000-0002-4968-0962 ; 0000-0002-7979-5699</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.28177$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.28177$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30673132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pashirzad, Mehran</creatorcontrib><creatorcontrib>Shafiee, Mojtaba</creatorcontrib><creatorcontrib>Avan, Amir</creatorcontrib><creatorcontrib>Ryzhikov, Mikhail</creatorcontrib><creatorcontrib>Fiuji, Hamid</creatorcontrib><creatorcontrib>Bahreyni, Amirhossein</creatorcontrib><creatorcontrib>Khazaei, Majid</creatorcontrib><creatorcontrib>Soleimanpour, Saman</creatorcontrib><creatorcontrib>Hassanian, Seyed Mahdi</creatorcontrib><title>Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Crocin is the major component of saffron, which is used in phytomedicine for the treatment of several diseases including diabetes, fatty liver, depression, menstruation disorders, and, of special interest in this review, inflammatory diseases. Promising selective anti‐inflammatory properties of this pharmacological active component have been observed in several studies. Saffron has been shown to exert anti‐inflammatory properties against several inflammatory diseases and can be used as a novel therapeutic agent for the treatment of inflammatory diseases either alone or in combination with other standard anti‐inflammatory agents. This review summarizes the protective role of saffron and its pharmacologically active constituents in the pathogenesis of inflammatory diseases including digestive diseases, dermatitis, asthma, atherosclerosis, and neurodegenerative diseases for a better understanding and hence a better management of these diseases.
Saffron has been shown to exert anti‐inflammatory properties against several inflammatory diseases and can be used as a novel therapeutic agent for the treatment of inflammatory diseases either alone or in combination with other standard anti‐inflammatory agents. This review summarizes the protective role of saffron and its pharmacologically active constituents in the pathogenesis of inflammatory diseases including digestive diseases, dermatitis, asthma, atherosclerosis, and neurodegenerative diseases for a better understanding and hence a better management of these diseases.</description><subject>Arteriosclerosis</subject><subject>Asthma</subject><subject>Atherosclerosis</subject><subject>Chemical compounds</subject><subject>crocin</subject><subject>Dermatitis</subject><subject>Diabetes mellitus</subject><subject>Digestive system diseases</subject><subject>Fatty liver</subject><subject>Inflammatory diseases</subject><subject>Liver diseases</subject><subject>Menstruation</subject><subject>Neurodegenerative diseases</subject><subject>Neurological diseases</subject><subject>Pathogenesis</subject><subject>Pharmacology</subject><subject>Saffron</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLxDAUhYMoOo4u_AMScKOL0TzapHEnxScDutB1iOmtdujLJFX6781YdSEIF-7ifBwOH0IHlJxSQtjZyvanLKNSbqAZJUouEpGyTTSLGV2oNKE7aNf7FSFEKc630Q4nQnLK2Qy9PL6CMz0MobK47wK0dsRdia3rbNXieOEVcHBgQgNtWEdVW9amaUzo3IiLyoPx4M9xPji3JnwwYfDYtAXuwfkebKjeYQ9tlab2sP_95-jp6vIxv1ks769v84vlwiY0Dk-NoEmRcC44lcBLoQS3wgAUiQSVFSm1oiRMWWIZyzIuiDUSntPEcJNmmeRzdDz19q57G8AH3VTeQl2bFrrBa0alSljGqIjo0R901Q2ujes0Y0xlKeVf1MlERSPeOyh176rGuFFTotf2dbSvv-xH9vC7cXhuoPglf3RH4GwCPqoaxv-b9F3-MFV-Aqg3jlo</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Pashirzad, Mehran</creator><creator>Shafiee, Mojtaba</creator><creator>Avan, Amir</creator><creator>Ryzhikov, Mikhail</creator><creator>Fiuji, Hamid</creator><creator>Bahreyni, Amirhossein</creator><creator>Khazaei, Majid</creator><creator>Soleimanpour, Saman</creator><creator>Hassanian, Seyed Mahdi</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4968-0962</orcidid><orcidid>https://orcid.org/0000-0002-7979-5699</orcidid></search><sort><creationdate>201909</creationdate><title>Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective</title><author>Pashirzad, Mehran ; Shafiee, Mojtaba ; Avan, Amir ; Ryzhikov, Mikhail ; Fiuji, Hamid ; Bahreyni, Amirhossein ; Khazaei, Majid ; Soleimanpour, Saman ; Hassanian, Seyed Mahdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4197-5a614d4336317e3f6963c6aeed47e98d51c6f029c0c2288360ca7eb54a3a58873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Arteriosclerosis</topic><topic>Asthma</topic><topic>Atherosclerosis</topic><topic>Chemical compounds</topic><topic>crocin</topic><topic>Dermatitis</topic><topic>Diabetes mellitus</topic><topic>Digestive system diseases</topic><topic>Fatty liver</topic><topic>Inflammatory diseases</topic><topic>Liver diseases</topic><topic>Menstruation</topic><topic>Neurodegenerative diseases</topic><topic>Neurological diseases</topic><topic>Pathogenesis</topic><topic>Pharmacology</topic><topic>Saffron</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pashirzad, Mehran</creatorcontrib><creatorcontrib>Shafiee, Mojtaba</creatorcontrib><creatorcontrib>Avan, Amir</creatorcontrib><creatorcontrib>Ryzhikov, Mikhail</creatorcontrib><creatorcontrib>Fiuji, Hamid</creatorcontrib><creatorcontrib>Bahreyni, Amirhossein</creatorcontrib><creatorcontrib>Khazaei, Majid</creatorcontrib><creatorcontrib>Soleimanpour, Saman</creatorcontrib><creatorcontrib>Hassanian, Seyed Mahdi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pashirzad, Mehran</au><au>Shafiee, Mojtaba</au><au>Avan, Amir</au><au>Ryzhikov, Mikhail</au><au>Fiuji, Hamid</au><au>Bahreyni, Amirhossein</au><au>Khazaei, Majid</au><au>Soleimanpour, Saman</au><au>Hassanian, Seyed Mahdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2019-09</date><risdate>2019</risdate><volume>234</volume><issue>9</issue><spage>14601</spage><epage>14611</epage><pages>14601-14611</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Crocin is the major component of saffron, which is used in phytomedicine for the treatment of several diseases including diabetes, fatty liver, depression, menstruation disorders, and, of special interest in this review, inflammatory diseases. Promising selective anti‐inflammatory properties of this pharmacological active component have been observed in several studies. Saffron has been shown to exert anti‐inflammatory properties against several inflammatory diseases and can be used as a novel therapeutic agent for the treatment of inflammatory diseases either alone or in combination with other standard anti‐inflammatory agents. This review summarizes the protective role of saffron and its pharmacologically active constituents in the pathogenesis of inflammatory diseases including digestive diseases, dermatitis, asthma, atherosclerosis, and neurodegenerative diseases for a better understanding and hence a better management of these diseases.
Saffron has been shown to exert anti‐inflammatory properties against several inflammatory diseases and can be used as a novel therapeutic agent for the treatment of inflammatory diseases either alone or in combination with other standard anti‐inflammatory agents. This review summarizes the protective role of saffron and its pharmacologically active constituents in the pathogenesis of inflammatory diseases including digestive diseases, dermatitis, asthma, atherosclerosis, and neurodegenerative diseases for a better understanding and hence a better management of these diseases.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30673132</pmid><doi>10.1002/jcp.28177</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4968-0962</orcidid><orcidid>https://orcid.org/0000-0002-7979-5699</orcidid></addata></record> |
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| subjects | Arteriosclerosis Asthma Atherosclerosis Chemical compounds crocin Dermatitis Diabetes mellitus Digestive system diseases Fatty liver Inflammatory diseases Liver diseases Menstruation Neurodegenerative diseases Neurological diseases Pathogenesis Pharmacology Saffron |
| title | Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective |
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