Midazolam Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study

OBJECTIVES:To develop a pharmacokinetic-pharmacogenomic population model of midazolam in critically ill children with primary respiratory failure. DESIGN:Prospective pharmacokinetic-pharmacogenomic observational study. SETTING:Thirteen PICUs across the United States. PATIENTS:Pediatric subjects mech...

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Veröffentlicht in:	Critical care medicine 2019-04, Vol.47 (4), p.e301-e309
Hauptverfasser:	Zuppa, Athena F., Conrado, Daniela J., Zane, Nicole R., Curley, Martha A. Q., Bradfield, Jonathan, Hakonarson, Hakon, Gastonguay, Madeleine S., Moorthy, Ganesh, Prodell, Janice, Gastonguay, Marc R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Child Critical Illness - therapy Dose-Response Relationship, Drug Humans Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - pharmacokinetics Male Midazolam - administration & dosage Midazolam - pharmacokinetics Pharmacogenomic Testing Prospective Studies Respiration, Artificial Respiratory Distress Syndrome, Adult - drug therapy Respiratory Distress Syndrome, Adult - physiopathology
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