Growth suppression of human oral cancer cells by candidate agents for cetuximab-side effects

Cetuximab, an inhibitor of the epidermal growth factor receptor that is used widely to treat human cancers including oral squamous cell carcinoma (OSCC), has characteristic side effects of skin rash and hypomagnesemia. However, the mechanisms of and therapeutic agents for skin rashes and hypomagnese...

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Veröffentlicht in:	Experimental cell research 2019-03, Vol.376 (2), p.210-220
Hauptverfasser:	Uzawa, Katsuhiro, Kasamatsu, Atsushi, Saito, Tomoaki, Kita, Akihiro, Sawai, Yuki, Toeda, Yuriko, Koike, Kazuyuki, Nakashima, Dai, Endo, Yosuke, Shiiba, Masashi, Takiguchi, Yuichi, Tanzawa, Hideki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Immunological - adverse effects Carcinoma, Squamous Cell - complications Carcinoma, Squamous Cell - drug therapy Cell Line, Tumor Cetuximab - adverse effects Cetuximab side effects Drug Therapy, Combination ErbB Receptors - antagonists & inhibitors Exanthema - chemically induced Exanthema - genetics Exanthema - prevention & control Female Flavagline Gene Expression Regulation, Neoplastic - drug effects Gene Regulatory Networks Growth Inhibitors - adverse effects Growth Inhibitors - antagonists & inhibitors Growth Inhibitors - therapeutic use HEK293 Cells Humans Hypercalciuria - chemically induced Hypercalciuria - genetics Hypercalciuria - prevention & control Imidazoles - therapeutic use MAP Kinase Signaling System - drug effects Mice Mice, Inbred BALB C Mice, Nude Mouth Neoplasms - complications Mouth Neoplasms - drug therapy Mouth Neoplasms - genetics Nephrocalcinosis - chemically induced Nephrocalcinosis - genetics Nephrocalcinosis - prevention & control p38 Pyridines - therapeutic use Renal Tubular Transport, Inborn Errors - chemically induced Renal Tubular Transport, Inborn Errors - genetics Renal Tubular Transport, Inborn Errors - prevention & control SB203580 Transcriptome TRPM6 Tumor growth suppression Xenograft Model Antitumor Assays
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