Assessing cross-reactivity of Junín virus-directed neutralizing antibodies

Arenaviruses cause several viral hemorrhagic fevers endemic to Africa and South America. The respective causative agents are classified as biosafety level (BSL) 4 pathogens. Unlike for most other BSL4 agents, for the New World arenavirus Junín virus (JUNV) both a highly effective vaccination (Candid...

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Veröffentlicht in:	Antiviral research 2019-03, Vol.163, p.106-116
Hauptverfasser:	Leske, Anne, Waßmann, Irke, Schnepel, Kevin, Shifflett, Kyle, Holzerland, Julia, Bostedt, Linus, Bohn, Patrick, Mettenleiter, Thomas C., Briggiler, Ana M., Brignone, Julia, Enria, Delia, Cordo, Sandra M., Hoenen, Thomas, Groseth, Allison
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antibody cross-reactivity Arenavirus Arenaviruses, New World - immunology Cross Reactions HEK293 Cells Hemorrhagic Fever, American - immunology Humans Junin virus - immunology JunÍn virus Neutralization assay Neutralizing antibodies Transcription and replication competent virus-like particle (trVLP) assay Virus Replication
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