A pilot randomized controlled trial of 6-week combined exercise program on fasting insulin and fitness levels in individuals with spinal cord injury
Purpose The aim of this randomized controlled trial study was to investigate the effect of combined exercise program on the fasting insulin and fitness levels of people with spinal cord injury (SCI). Methods A total of 19 individuals with SCI participated in a combined exercise program consisting of...
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| Veröffentlicht in: | European spine journal 2019-05, Vol.28 (5), p.1082-1091 |
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| container_title | European spine journal |
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| creator | Kim, Dong-Il Taylor, J. Andrew Tan, Can Ozan Park, Hyuna Kim, Ji Young Park, Sang-Yong Chung, Kyong-Mee Lee, Young-Hee Lee, Bum-Suk Jeon, Justin Y. |
| description | Purpose
The aim of this randomized controlled trial study was to investigate the effect of combined exercise program on the fasting insulin and fitness levels of people with spinal cord injury (SCI).
Methods
A total of 19 individuals with SCI participated in a combined exercise program consisting of aerobic and resistance exercises for 60 min per day, 3 days per week for 6 weeks. Peak oxygen consumption, body mass index, percent body fat, waist circumference, shoulder abduction and adduction, shoulder flexion and extension, elbow flexion and extension, fasting insulin levels, and homeostasis model assessment of insulin resistance (HOMA-IR) levels were measured at baseline and after the intervention.
Results
The 6-week exercise program significantly decreased the average fasting insulin (baseline: 7.5 ± 4.7 µU/ml vs. post-intervention: 4.5 ± 2.2 µU/ml,
p |
| doi_str_mv | 10.1007/s00586-019-05885-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179426068</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2179426068</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-9839421c96efad9f47046b11a78e03aa21f4ea6a7cb93f99826884f827c53213</originalsourceid><addsrcrecordid>eNp9kU1vFSEUhonR2Gv1D7gwJG66QfmYgWHZNH4lTdx0T7jM4cp1Bq4w01p_hz-4x96qiQsTEg55n_Me4CXkpeBvBOfmbeO8HzTjwjIshp6ZR2QjOiUZt0o-JhtuO860EfaEPGttz7noLddPyYnieuBaqQ35eU4PaSoLrT6PZU4_YKSh5KWWacJyqclPtESq2Q3AV5TmbcoowHeoITWgh1p21c-0ZBp9W1Le0ZTbOqVM0ZHGtGRojU5wDVNDCdeYrtO4ejzepOULbYeUcUgodURxv9bb5-RJRBlePOyn5Or9u6uLj-zy84dPF-eXLCjTL8wOynZSBKsh-tHGzvBOb4XwZgCuvJciduC1N2FrVbR2kHoYujhIE3olhTolZ0dbfMO3Fdri5tQCTJPPUNbmpDDor_GvEH39D7ova8Vr31PcWGlkj5Q8UqGW1ipEd6hp9vXWCe5-ReaOkTmMzN1H5gw2vXqwXrczjH9afmeEgDoCDaW8g_p39n9s7wDYw6NH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2170792725</pqid></control><display><type>article</type><title>A pilot randomized controlled trial of 6-week combined exercise program on fasting insulin and fitness levels in individuals with spinal cord injury</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kim, Dong-Il ; Taylor, J. Andrew ; Tan, Can Ozan ; Park, Hyuna ; Kim, Ji Young ; Park, Sang-Yong ; Chung, Kyong-Mee ; Lee, Young-Hee ; Lee, Bum-Suk ; Jeon, Justin Y.</creator><creatorcontrib>Kim, Dong-Il ; Taylor, J. Andrew ; Tan, Can Ozan ; Park, Hyuna ; Kim, Ji Young ; Park, Sang-Yong ; Chung, Kyong-Mee ; Lee, Young-Hee ; Lee, Bum-Suk ; Jeon, Justin Y.</creatorcontrib><description>Purpose
The aim of this randomized controlled trial study was to investigate the effect of combined exercise program on the fasting insulin and fitness levels of people with spinal cord injury (SCI).
Methods
A total of 19 individuals with SCI participated in a combined exercise program consisting of aerobic and resistance exercises for 60 min per day, 3 days per week for 6 weeks. Peak oxygen consumption, body mass index, percent body fat, waist circumference, shoulder abduction and adduction, shoulder flexion and extension, elbow flexion and extension, fasting insulin levels, and homeostasis model assessment of insulin resistance (HOMA-IR) levels were measured at baseline and after the intervention.
Results
The 6-week exercise program significantly decreased the average fasting insulin (baseline: 7.5 ± 4.7 µU/ml vs. post-intervention: 4.5 ± 2.2 µU/ml,
p
< 0.05) and HOMA-IR (baseline: 1.5 ± 1.0 vs. post-intervention: 0.9 ± 0.4,
p
< 0.05) in the exercise group, whereas there was no change in control group (between group difference, mean fasting insulin: − 3.2 µU/ml,
p
= 0.003; mean HOMA-IR: − 0.66,
p
= 0.001). In addition, muscle strength of the shoulder flexors, extensors, abductors, adductors, and elbow flexors was significantly improved in the exercise group compared to the controls.
Conclusion
A combined exercise program is effective in decreasing fasting insulin and HOMA-IR levels while improving fitness in those with SCI.
Graphical abstract
These slides can be retrieved under Electronic Supplementary Material.</description><identifier>ISSN: 0940-6719</identifier><identifier>EISSN: 1432-0932</identifier><identifier>DOI: 10.1007/s00586-019-05885-7</identifier><identifier>PMID: 30680633</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Body fat ; Body mass index ; Clinical trials ; Elbow ; Exercise ; Exercise Therapy ; Fasting ; Homeostasis ; Humans ; Insulin ; Insulin - blood ; Insulin resistance ; Medicine ; Medicine & Public Health ; Muscle strength ; Muscle Strength - physiology ; Neurosurgery ; Original Article ; Oxygen consumption ; Physical fitness ; Pilot Projects ; Shoulder ; Spinal cord injuries ; Spinal Cord Injuries - therapy ; Surgical Orthopedics</subject><ispartof>European spine journal, 2019-05, Vol.28 (5), p.1082-1091</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>European Spine Journal is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-9839421c96efad9f47046b11a78e03aa21f4ea6a7cb93f99826884f827c53213</citedby><cites>FETCH-LOGICAL-c375t-9839421c96efad9f47046b11a78e03aa21f4ea6a7cb93f99826884f827c53213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00586-019-05885-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00586-019-05885-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30680633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Dong-Il</creatorcontrib><creatorcontrib>Taylor, J. Andrew</creatorcontrib><creatorcontrib>Tan, Can Ozan</creatorcontrib><creatorcontrib>Park, Hyuna</creatorcontrib><creatorcontrib>Kim, Ji Young</creatorcontrib><creatorcontrib>Park, Sang-Yong</creatorcontrib><creatorcontrib>Chung, Kyong-Mee</creatorcontrib><creatorcontrib>Lee, Young-Hee</creatorcontrib><creatorcontrib>Lee, Bum-Suk</creatorcontrib><creatorcontrib>Jeon, Justin Y.</creatorcontrib><title>A pilot randomized controlled trial of 6-week combined exercise program on fasting insulin and fitness levels in individuals with spinal cord injury</title><title>European spine journal</title><addtitle>Eur Spine J</addtitle><addtitle>Eur Spine J</addtitle><description>Purpose
The aim of this randomized controlled trial study was to investigate the effect of combined exercise program on the fasting insulin and fitness levels of people with spinal cord injury (SCI).
Methods
A total of 19 individuals with SCI participated in a combined exercise program consisting of aerobic and resistance exercises for 60 min per day, 3 days per week for 6 weeks. Peak oxygen consumption, body mass index, percent body fat, waist circumference, shoulder abduction and adduction, shoulder flexion and extension, elbow flexion and extension, fasting insulin levels, and homeostasis model assessment of insulin resistance (HOMA-IR) levels were measured at baseline and after the intervention.
Results
The 6-week exercise program significantly decreased the average fasting insulin (baseline: 7.5 ± 4.7 µU/ml vs. post-intervention: 4.5 ± 2.2 µU/ml,
p
< 0.05) and HOMA-IR (baseline: 1.5 ± 1.0 vs. post-intervention: 0.9 ± 0.4,
p
< 0.05) in the exercise group, whereas there was no change in control group (between group difference, mean fasting insulin: − 3.2 µU/ml,
p
= 0.003; mean HOMA-IR: − 0.66,
p
= 0.001). In addition, muscle strength of the shoulder flexors, extensors, abductors, adductors, and elbow flexors was significantly improved in the exercise group compared to the controls.
Conclusion
A combined exercise program is effective in decreasing fasting insulin and HOMA-IR levels while improving fitness in those with SCI.
Graphical abstract
These slides can be retrieved under Electronic Supplementary Material.</description><subject>Body fat</subject><subject>Body mass index</subject><subject>Clinical trials</subject><subject>Elbow</subject><subject>Exercise</subject><subject>Exercise Therapy</subject><subject>Fasting</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin resistance</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Muscle strength</subject><subject>Muscle Strength - physiology</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Oxygen consumption</subject><subject>Physical fitness</subject><subject>Pilot Projects</subject><subject>Shoulder</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - therapy</subject><subject>Surgical Orthopedics</subject><issn>0940-6719</issn><issn>1432-0932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1vFSEUhonR2Gv1D7gwJG66QfmYgWHZNH4lTdx0T7jM4cp1Bq4w01p_hz-4x96qiQsTEg55n_Me4CXkpeBvBOfmbeO8HzTjwjIshp6ZR2QjOiUZt0o-JhtuO860EfaEPGttz7noLddPyYnieuBaqQ35eU4PaSoLrT6PZU4_YKSh5KWWacJyqclPtESq2Q3AV5TmbcoowHeoITWgh1p21c-0ZBp9W1Le0ZTbOqVM0ZHGtGRojU5wDVNDCdeYrtO4ejzepOULbYeUcUgodURxv9bb5-RJRBlePOyn5Or9u6uLj-zy84dPF-eXLCjTL8wOynZSBKsh-tHGzvBOb4XwZgCuvJciduC1N2FrVbR2kHoYujhIE3olhTolZ0dbfMO3Fdri5tQCTJPPUNbmpDDor_GvEH39D7ova8Vr31PcWGlkj5Q8UqGW1ipEd6hp9vXWCe5-ReaOkTmMzN1H5gw2vXqwXrczjH9afmeEgDoCDaW8g_p39n9s7wDYw6NH</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Kim, Dong-Il</creator><creator>Taylor, J. Andrew</creator><creator>Tan, Can Ozan</creator><creator>Park, Hyuna</creator><creator>Kim, Ji Young</creator><creator>Park, Sang-Yong</creator><creator>Chung, Kyong-Mee</creator><creator>Lee, Young-Hee</creator><creator>Lee, Bum-Suk</creator><creator>Jeon, Justin Y.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190501</creationdate><title>A pilot randomized controlled trial of 6-week combined exercise program on fasting insulin and fitness levels in individuals with spinal cord injury</title><author>Kim, Dong-Il ; Taylor, J. Andrew ; Tan, Can Ozan ; Park, Hyuna ; Kim, Ji Young ; Park, Sang-Yong ; Chung, Kyong-Mee ; Lee, Young-Hee ; Lee, Bum-Suk ; Jeon, Justin Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-9839421c96efad9f47046b11a78e03aa21f4ea6a7cb93f99826884f827c53213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Body fat</topic><topic>Body mass index</topic><topic>Clinical trials</topic><topic>Elbow</topic><topic>Exercise</topic><topic>Exercise Therapy</topic><topic>Fasting</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin resistance</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Muscle strength</topic><topic>Muscle Strength - physiology</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Oxygen consumption</topic><topic>Physical fitness</topic><topic>Pilot Projects</topic><topic>Shoulder</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - therapy</topic><topic>Surgical Orthopedics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Dong-Il</creatorcontrib><creatorcontrib>Taylor, J. Andrew</creatorcontrib><creatorcontrib>Tan, Can Ozan</creatorcontrib><creatorcontrib>Park, Hyuna</creatorcontrib><creatorcontrib>Kim, Ji Young</creatorcontrib><creatorcontrib>Park, Sang-Yong</creatorcontrib><creatorcontrib>Chung, Kyong-Mee</creatorcontrib><creatorcontrib>Lee, Young-Hee</creatorcontrib><creatorcontrib>Lee, Bum-Suk</creatorcontrib><creatorcontrib>Jeon, Justin Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European spine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Dong-Il</au><au>Taylor, J. Andrew</au><au>Tan, Can Ozan</au><au>Park, Hyuna</au><au>Kim, Ji Young</au><au>Park, Sang-Yong</au><au>Chung, Kyong-Mee</au><au>Lee, Young-Hee</au><au>Lee, Bum-Suk</au><au>Jeon, Justin Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pilot randomized controlled trial of 6-week combined exercise program on fasting insulin and fitness levels in individuals with spinal cord injury</atitle><jtitle>European spine journal</jtitle><stitle>Eur Spine J</stitle><addtitle>Eur Spine J</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>28</volume><issue>5</issue><spage>1082</spage><epage>1091</epage><pages>1082-1091</pages><issn>0940-6719</issn><eissn>1432-0932</eissn><abstract>Purpose
The aim of this randomized controlled trial study was to investigate the effect of combined exercise program on the fasting insulin and fitness levels of people with spinal cord injury (SCI).
Methods
A total of 19 individuals with SCI participated in a combined exercise program consisting of aerobic and resistance exercises for 60 min per day, 3 days per week for 6 weeks. Peak oxygen consumption, body mass index, percent body fat, waist circumference, shoulder abduction and adduction, shoulder flexion and extension, elbow flexion and extension, fasting insulin levels, and homeostasis model assessment of insulin resistance (HOMA-IR) levels were measured at baseline and after the intervention.
Results
The 6-week exercise program significantly decreased the average fasting insulin (baseline: 7.5 ± 4.7 µU/ml vs. post-intervention: 4.5 ± 2.2 µU/ml,
p
< 0.05) and HOMA-IR (baseline: 1.5 ± 1.0 vs. post-intervention: 0.9 ± 0.4,
p
< 0.05) in the exercise group, whereas there was no change in control group (between group difference, mean fasting insulin: − 3.2 µU/ml,
p
= 0.003; mean HOMA-IR: − 0.66,
p
= 0.001). In addition, muscle strength of the shoulder flexors, extensors, abductors, adductors, and elbow flexors was significantly improved in the exercise group compared to the controls.
Conclusion
A combined exercise program is effective in decreasing fasting insulin and HOMA-IR levels while improving fitness in those with SCI.
Graphical abstract
These slides can be retrieved under Electronic Supplementary Material.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30680633</pmid><doi>10.1007/s00586-019-05885-7</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0940-6719 |
| ispartof | European spine journal, 2019-05, Vol.28 (5), p.1082-1091 |
| issn | 0940-6719 1432-0932 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2179426068 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Body fat Body mass index Clinical trials Elbow Exercise Exercise Therapy Fasting Homeostasis Humans Insulin Insulin - blood Insulin resistance Medicine Medicine & Public Health Muscle strength Muscle Strength - physiology Neurosurgery Original Article Oxygen consumption Physical fitness Pilot Projects Shoulder Spinal cord injuries Spinal Cord Injuries - therapy Surgical Orthopedics |
| title | A pilot randomized controlled trial of 6-week combined exercise program on fasting insulin and fitness levels in individuals with spinal cord injury |
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