Genomic profiling of combined hepatocellular‐cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma

Combined hepatocellular‐cholangiocarcinomas (CHC) are mixed tumours with both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) components. CHC prognosis is similar to intrahepatic CC (ICC) and worse than HCC; staging and treatment generally follow ICC algorithms. However, the molecular bio...

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Veröffentlicht in:	The Journal of pathology 2019-06, Vol.248 (2), p.164-178
Hauptverfasser:	Joseph, Nancy M, Tsokos, Christos G, Umetsu, Sarah E, Shain, A Hunter, Kelley, Robin K, Onodera, Courtney, Bowman, Sarah, Talevich, Eric, Ferrell, Linda D, Kakar, Sanjay, Krings, Gregor
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers, Tumor - genetics c-Met protein Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology CCND1 Cell cycle Cholangiocarcinoma Cholangiocarcinoma - genetics Cholangiocarcinoma - pathology Chromatin Cirrhosis combined hepatocellular‐cholangiocarcinoma ErbB-2 protein ERBB2 Female Fibroblast growth factor receptor 2 Gene Dosage Gene Expression Profiling Gene Rearrangement Genetic Predisposition to Disease Genetics genomic profile HCC‐CC Hepatocellular carcinoma hepatocholangiocarcinoma Heterogeneity High-Throughput Nucleotide Sequencing Humans Liver cancer Liver cirrhosis Liver Neoplasms - genetics Liver Neoplasms - pathology Male MET Middle Aged mixed hepatocellular‐cholangiocarcinoma Molecular biology Mutation MYC Neoplasms, Complex and Mixed - genetics Neoplasms, Complex and Mixed - pathology next‐generation sequencing p53 Protein Protein-tyrosine kinase receptors PTEN protein TERT TP53 Transcriptome Tumors Wnt protein
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