Topical Retinoids in Acne Vulgaris: A Systematic Review
Background Topical retinoids are a first-line treatment for acne vulgaris. Objective This systematic review aims to evaluate the efficacy, safety, and tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris. Methods A PubMed and Embase search was conducted...
Gespeichert in:
| Veröffentlicht in: | American journal of clinical dermatology 2019-06, Vol.20 (3), p.345-365 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 365 |
|---|---|
| container_issue | 3 |
| container_start_page | 345 |
| container_title | American journal of clinical dermatology |
| container_volume | 20 |
| creator | Kolli, Sree S. Pecone, Danielle Pona, Adrian Cline, Abigail Feldman, Steven R. |
| description | Background
Topical retinoids are a first-line treatment for acne vulgaris.
Objective
This systematic review aims to evaluate the efficacy, safety, and tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris.
Methods
A PubMed and Embase search was conducted using the search terms ‘adapalene,’ ‘tretinoin,’ ‘tazarotene,’ and ‘acne vulgaris.’ Selection of articles fit the following inclusion criteria: clinical trials evaluating both efficacy and safety/tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris and published between January 1, 2008 and September 1, 2018. Exclusion criteria included clinical trials involving 20 subjects or fewer, subjects under 12 years of age, and topical retinoid combination therapies with moisturizers or aloe vera. Of 424 search results found, a total of 54 clinical trials were chosen based on selection criteria.
Results
Topical retinoids are superior to vehicle in improving Investigator Global Assessment and Investigator’s Static Global Assessment (24.1–28.8% and 13.3–17.3%, respectively;
p |
| doi_str_mv | 10.1007/s40257-019-00423-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179423179</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2260095785</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-3ce5c97d1f2305531d5d3c7346c650506cc8e90a5a7cb9210f099dfdea1e5ed3</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMoTqd_wAspeONN9CRpmsa7MfyCgaDD25Al6cjo2tm0yvbrjetU8EIC-SDPeZPzIHRG4IoAiOuQAuUCA5EYIKUMb_bQESFCYpLn-f52zzHwjAzQcQgLABpHdogGDDKRxuMREtN65Y0uk2fX-qr2NiS-SkamcslrV85148NNMkpe1qF1S916E8F37z5O0EGhy-BOd-sQTe9up-MHPHm6fxyPJtgwwVvMjONGCksKyoBzRiy3zAiWZibjwCEzJncSNNfCzCQlUICUtrBOE8edZUN02ceumvqtc6FVSx-MK0tduboLisZuY-dxjujFH3RRd00VP6cozQAkFzmPFO0p09QhNK5Qq8YvdbNWBNSXVdVbVdGq2lpVm1h0vovuZktnf0q-NUaA9UCIV9XcNb9v_xP7CXX_gMo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2260095785</pqid></control><display><type>article</type><title>Topical Retinoids in Acne Vulgaris: A Systematic Review</title><source>SpringerLink Journals - AutoHoldings</source><creator>Kolli, Sree S. ; Pecone, Danielle ; Pona, Adrian ; Cline, Abigail ; Feldman, Steven R.</creator><creatorcontrib>Kolli, Sree S. ; Pecone, Danielle ; Pona, Adrian ; Cline, Abigail ; Feldman, Steven R.</creatorcontrib><description>Background
Topical retinoids are a first-line treatment for acne vulgaris.
Objective
This systematic review aims to evaluate the efficacy, safety, and tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris.
Methods
A PubMed and Embase search was conducted using the search terms ‘adapalene,’ ‘tretinoin,’ ‘tazarotene,’ and ‘acne vulgaris.’ Selection of articles fit the following inclusion criteria: clinical trials evaluating both efficacy and safety/tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris and published between January 1, 2008 and September 1, 2018. Exclusion criteria included clinical trials involving 20 subjects or fewer, subjects under 12 years of age, and topical retinoid combination therapies with moisturizers or aloe vera. Of 424 search results found, a total of 54 clinical trials were chosen based on selection criteria.
Results
Topical retinoids are superior to vehicle in improving Investigator Global Assessment and Investigator’s Static Global Assessment (24.1–28.8% and 13.3–17.3%, respectively;
p
< 0.001). A topical retinoid combined with benzoyl peroxide led to IGA improvement compared with vehicle (26.1–34.9% vs 7–11.8%;
p
< 0.001) at Week 12. Topical retinoid plus an oral antibiotic was superior to vehicle in reducing lesion counts (64–78.9% vs 41–56.8%,
p
< 0.001). There was no significant difference in efficacy between tretinoin and tazarotene. Tretinoin 0.05% resulted in 62% of patients experiencing AEs compared with adapalene 0.1% (19%) and adapalene 0.3% (40%). More patients receiving adapalene were tolerant of the AEs compared with tazarotene (55.4% vs 24.4%;
p
< 0.0012).
Conclusions
Topical retinoids are safe and efficacious for the treatment of acne vulgaris. They should be used in combination with benzoyl peroxide to optimize results in patients. The differences in efficacy of topical retinoids appears minor; therefore, the type of topical retinoid is not as important as choosing a particular strength of topical retinoid and combining it with an antimicrobial agent. Adapalene has a superior tolerability profile amongst topical retinoids.</description><identifier>ISSN: 1175-0561</identifier><identifier>EISSN: 1179-1888</identifier><identifier>DOI: 10.1007/s40257-019-00423-z</identifier><identifier>PMID: 30674002</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Acne ; Antibiotics ; Antimicrobial agents ; Clinical trials ; Dermatology ; Drugs ; Evidence-based medicine ; FDA approval ; Medicine ; Medicine & Public Health ; Pharmacology/Toxicology ; Pharmacotherapy ; Signal transduction ; Systematic Review</subject><ispartof>American journal of clinical dermatology, 2019-06, Vol.20 (3), p.345-365</ispartof><rights>Springer Nature Switzerland AG 2019</rights><rights>Copyright Springer Nature B.V. Jun 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-3ce5c97d1f2305531d5d3c7346c650506cc8e90a5a7cb9210f099dfdea1e5ed3</citedby><cites>FETCH-LOGICAL-c375t-3ce5c97d1f2305531d5d3c7346c650506cc8e90a5a7cb9210f099dfdea1e5ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40257-019-00423-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40257-019-00423-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30674002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kolli, Sree S.</creatorcontrib><creatorcontrib>Pecone, Danielle</creatorcontrib><creatorcontrib>Pona, Adrian</creatorcontrib><creatorcontrib>Cline, Abigail</creatorcontrib><creatorcontrib>Feldman, Steven R.</creatorcontrib><title>Topical Retinoids in Acne Vulgaris: A Systematic Review</title><title>American journal of clinical dermatology</title><addtitle>Am J Clin Dermatol</addtitle><addtitle>Am J Clin Dermatol</addtitle><description>Background
Topical retinoids are a first-line treatment for acne vulgaris.
Objective
This systematic review aims to evaluate the efficacy, safety, and tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris.
Methods
A PubMed and Embase search was conducted using the search terms ‘adapalene,’ ‘tretinoin,’ ‘tazarotene,’ and ‘acne vulgaris.’ Selection of articles fit the following inclusion criteria: clinical trials evaluating both efficacy and safety/tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris and published between January 1, 2008 and September 1, 2018. Exclusion criteria included clinical trials involving 20 subjects or fewer, subjects under 12 years of age, and topical retinoid combination therapies with moisturizers or aloe vera. Of 424 search results found, a total of 54 clinical trials were chosen based on selection criteria.
Results
Topical retinoids are superior to vehicle in improving Investigator Global Assessment and Investigator’s Static Global Assessment (24.1–28.8% and 13.3–17.3%, respectively;
p
< 0.001). A topical retinoid combined with benzoyl peroxide led to IGA improvement compared with vehicle (26.1–34.9% vs 7–11.8%;
p
< 0.001) at Week 12. Topical retinoid plus an oral antibiotic was superior to vehicle in reducing lesion counts (64–78.9% vs 41–56.8%,
p
< 0.001). There was no significant difference in efficacy between tretinoin and tazarotene. Tretinoin 0.05% resulted in 62% of patients experiencing AEs compared with adapalene 0.1% (19%) and adapalene 0.3% (40%). More patients receiving adapalene were tolerant of the AEs compared with tazarotene (55.4% vs 24.4%;
p
< 0.0012).
Conclusions
Topical retinoids are safe and efficacious for the treatment of acne vulgaris. They should be used in combination with benzoyl peroxide to optimize results in patients. The differences in efficacy of topical retinoids appears minor; therefore, the type of topical retinoid is not as important as choosing a particular strength of topical retinoid and combining it with an antimicrobial agent. Adapalene has a superior tolerability profile amongst topical retinoids.</description><subject>Acne</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Clinical trials</subject><subject>Dermatology</subject><subject>Drugs</subject><subject>Evidence-based medicine</subject><subject>FDA approval</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacotherapy</subject><subject>Signal transduction</subject><subject>Systematic Review</subject><issn>1175-0561</issn><issn>1179-1888</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kF1LwzAUhoMoTqd_wAspeONN9CRpmsa7MfyCgaDD25Al6cjo2tm0yvbrjetU8EIC-SDPeZPzIHRG4IoAiOuQAuUCA5EYIKUMb_bQESFCYpLn-f52zzHwjAzQcQgLABpHdogGDDKRxuMREtN65Y0uk2fX-qr2NiS-SkamcslrV85148NNMkpe1qF1S916E8F37z5O0EGhy-BOd-sQTe9up-MHPHm6fxyPJtgwwVvMjONGCksKyoBzRiy3zAiWZibjwCEzJncSNNfCzCQlUICUtrBOE8edZUN02ceumvqtc6FVSx-MK0tduboLisZuY-dxjujFH3RRd00VP6cozQAkFzmPFO0p09QhNK5Qq8YvdbNWBNSXVdVbVdGq2lpVm1h0vovuZktnf0q-NUaA9UCIV9XcNb9v_xP7CXX_gMo</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Kolli, Sree S.</creator><creator>Pecone, Danielle</creator><creator>Pona, Adrian</creator><creator>Cline, Abigail</creator><creator>Feldman, Steven R.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>Topical Retinoids in Acne Vulgaris: A Systematic Review</title><author>Kolli, Sree S. ; Pecone, Danielle ; Pona, Adrian ; Cline, Abigail ; Feldman, Steven R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-3ce5c97d1f2305531d5d3c7346c650506cc8e90a5a7cb9210f099dfdea1e5ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acne</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Clinical trials</topic><topic>Dermatology</topic><topic>Drugs</topic><topic>Evidence-based medicine</topic><topic>FDA approval</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacotherapy</topic><topic>Signal transduction</topic><topic>Systematic Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kolli, Sree S.</creatorcontrib><creatorcontrib>Pecone, Danielle</creatorcontrib><creatorcontrib>Pona, Adrian</creatorcontrib><creatorcontrib>Cline, Abigail</creatorcontrib><creatorcontrib>Feldman, Steven R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kolli, Sree S.</au><au>Pecone, Danielle</au><au>Pona, Adrian</au><au>Cline, Abigail</au><au>Feldman, Steven R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical Retinoids in Acne Vulgaris: A Systematic Review</atitle><jtitle>American journal of clinical dermatology</jtitle><stitle>Am J Clin Dermatol</stitle><addtitle>Am J Clin Dermatol</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>20</volume><issue>3</issue><spage>345</spage><epage>365</epage><pages>345-365</pages><issn>1175-0561</issn><eissn>1179-1888</eissn><abstract>Background
Topical retinoids are a first-line treatment for acne vulgaris.
Objective
This systematic review aims to evaluate the efficacy, safety, and tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris.
Methods
A PubMed and Embase search was conducted using the search terms ‘adapalene,’ ‘tretinoin,’ ‘tazarotene,’ and ‘acne vulgaris.’ Selection of articles fit the following inclusion criteria: clinical trials evaluating both efficacy and safety/tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris and published between January 1, 2008 and September 1, 2018. Exclusion criteria included clinical trials involving 20 subjects or fewer, subjects under 12 years of age, and topical retinoid combination therapies with moisturizers or aloe vera. Of 424 search results found, a total of 54 clinical trials were chosen based on selection criteria.
Results
Topical retinoids are superior to vehicle in improving Investigator Global Assessment and Investigator’s Static Global Assessment (24.1–28.8% and 13.3–17.3%, respectively;
p
< 0.001). A topical retinoid combined with benzoyl peroxide led to IGA improvement compared with vehicle (26.1–34.9% vs 7–11.8%;
p
< 0.001) at Week 12. Topical retinoid plus an oral antibiotic was superior to vehicle in reducing lesion counts (64–78.9% vs 41–56.8%,
p
< 0.001). There was no significant difference in efficacy between tretinoin and tazarotene. Tretinoin 0.05% resulted in 62% of patients experiencing AEs compared with adapalene 0.1% (19%) and adapalene 0.3% (40%). More patients receiving adapalene were tolerant of the AEs compared with tazarotene (55.4% vs 24.4%;
p
< 0.0012).
Conclusions
Topical retinoids are safe and efficacious for the treatment of acne vulgaris. They should be used in combination with benzoyl peroxide to optimize results in patients. The differences in efficacy of topical retinoids appears minor; therefore, the type of topical retinoid is not as important as choosing a particular strength of topical retinoid and combining it with an antimicrobial agent. Adapalene has a superior tolerability profile amongst topical retinoids.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30674002</pmid><doi>10.1007/s40257-019-00423-z</doi><tpages>21</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1175-0561 |
| ispartof | American journal of clinical dermatology, 2019-06, Vol.20 (3), p.345-365 |
| issn | 1175-0561 1179-1888 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2179423179 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Acne Antibiotics Antimicrobial agents Clinical trials Dermatology Drugs Evidence-based medicine FDA approval Medicine Medicine & Public Health Pharmacology/Toxicology Pharmacotherapy Signal transduction Systematic Review |
| title | Topical Retinoids in Acne Vulgaris: A Systematic Review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T22%3A30%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Topical%20Retinoids%20in%20Acne%20Vulgaris:%20A%20Systematic%20Review&rft.jtitle=American%20journal%20of%20clinical%20dermatology&rft.au=Kolli,%20Sree%20S.&rft.date=2019-06-01&rft.volume=20&rft.issue=3&rft.spage=345&rft.epage=365&rft.pages=345-365&rft.issn=1175-0561&rft.eissn=1179-1888&rft_id=info:doi/10.1007/s40257-019-00423-z&rft_dat=%3Cproquest_cross%3E2260095785%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2260095785&rft_id=info:pmid/30674002&rfr_iscdi=true |