A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity

Inosine 5′-monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting step in the de novo GTP biosynthetic pathway and plays essential roles in cell proliferation. As a clinical target, IMPDH has been studied for decades, but it has only been within the last years that we are starting to unders...

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Veröffentlicht in:	Journal of molecular biology 2019-03, Vol.431 (5), p.956-969
Hauptverfasser:	Fernández-Justel, David, Núñez, Rafael, Martín-Benito, Jaime, Jimeno, David, González-López, Adrián, Soriano, Eva María, Revuelta, José Luis, Buey, Rubén M.
Format:	Artikel
Sprache:	eng
Schlagworte:	allosteric regulation Catalysis Cell Line, Tumor Cell Proliferation - physiology conformational switch cytoophidia Guanosine Triphosphate - metabolism HeLa Cells Humans IMP dehydrogenase IMP Dehydrogenase - metabolism Molecular Conformation Nucleotides - metabolism Polymerization x-ray crystallography and scattering
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