Intervertebral disc regeneration with an adipose mesenchymal stem cell-derived tissue-engineered construct in a rat nucleotomy model

[Display omitted] Low back pain results in more global disabilities than any other condition, and intervertebral disc (IVD) degeneration is commonly involved in the etiology. Supplementation of IVDs with reparative cells is a rational strategy to address such clinical problems. We have previously de...

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Veröffentlicht in:	Acta biomaterialia 2019-03, Vol.87, p.118-129
Hauptverfasser:	Ishiguro, Hiroyuki, Kaito, Takashi, Yarimitsu, Seido, Hashimoto, Kunihiko, Okada, Rintaro, Kushioka, Junichi, Chijimatsu, Ryota, Takenaka, Shota, Makino, Takahiro, Sakai, Yusuke, Moriguchi, Yu, Otsuru, Satoru, Hart, David A., Fujie, Hiromichi, Nakamura, Norimasa, Yoshikawa, Hideki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Adipose Tissue - pathology Age Allografts Animals Biomaterials Biomechanics Cartilage Cartilage (articular) Cartilage, Articular - metabolism Cartilage, Articular - pathology Cells, Immobilized - metabolism Cells, Immobilized - pathology Cells, Immobilized - transplantation Construction engineering Degeneration Disabilities Disease Models, Animal Etiology Implantation Intervertebral disc Intervertebral Disc - cytology Intervertebral Disc - physiology Intervertebral Disc Degeneration - metabolism Intervertebral Disc Degeneration - pathology Intervertebral Disc Degeneration - therapy Intervertebral discs Low back pain Meniscus Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Mesenchymal Stem Cells - pathology Mesenchyme Pain Rats Rats, Transgenic Regeneration Stem cell transplantation Stem cells Supplements Tissue engineering Tissue Scaffolds - chemistry Total nucleotomy
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